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Transjugular intrahepatic portosystemic shunt (TIPSS) is an effective treatment for portal hypertension and its complications. However, no established guidelines for the treatment of symptomatic portal hypertension in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients are currently available. In addition, only limited information exists about the consequence of <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> implantation in patients with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy, safety and overall survival in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients who underwent <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients with portal hypertension who were treated with <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> between 1995 and 2012 were included in the analysis. Medical records and imaging studies were analysed. The indication for <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> implantation, procedure\u2010related complications, treatment success and overall survival were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> implantation was performed in 23 patients (57.5%) due to treatment refractory ascites, in 14 patients (35.0%) due to recurrent variceal bleeding and in three patients (7.5%) due to ascites and variceal bleeding. Primary technical success was assessed in all patients. After <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> implantation, no variceal bleeding reoccurred and ascites was controlled in 74.1%. No severe procedure\u2010related complications and no deterioration of liver function were observed. Post\u2010<jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> hepatic encephalopathy occurred in 40.0% of all patients. 30\u2010day, 90\u2010day\u2010, 1\u2010year\u2010 and 5\u2010year survival rates were 97.5%, 75.0%, 42.5% and 7.5%, respectively. Median overall survival after <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> implantation was 180 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transjugular intrahepatic portosystemic shunt implantation is an effective and safe treatment for portal hypertension in patients with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12994","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T11:05:31Z","timestamp":1413803131000},"page":"126-136","source":"Crossref","is-referenced-by-count":47,"title":["Efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPSS) in 40 patients with hepatocellular carcinoma"],"prefix":"10.1111","volume":"41","author":[{"given":"D.","family":"Bettinger","sequence":"first","affiliation":[{"name":"Department of Medicine II University Hospital Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kn\u00fcppel","sequence":"additional","affiliation":[{"name":"Department of Medicine II University Hospital Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Euringer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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