{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:58:56Z","timestamp":1769601536199,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hong Kong Jockey Club Charities Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Serrated polyps of the colorectum have distinct histological features and malignant potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the association between the presence of serrated polyps and synchronous advanced colorectal neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 4989 asymptomatic Chinese individuals aged 50\u201370\u00a0years who underwent screening colonoscopy, 281 cases with advanced neoplasia (adenoma \u22651\u00a0cm, with tubulovillous\/villous histology, with high\u2010grade dysplasia, or invasive adenocarcinoma) were compared with 4708 controls without advanced neoplasia for age, sex, smoking history, body mass index, family history of colorectal cancer and the presence of serrated polyps. Independent predictors of advanced neoplasia were determined by multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of advanced neoplasia and serrated polyps (excluding small distal hyperplastic polyps) was 5.7% and 5.6%, respectively. 3.7% and 0.4% subjects had proximal and large (\u226510\u00a0mm) serrated polyps, respectively. Independent predictors of synchronous advanced colorectal neoplasia were the presence of sessile serrated adenomas (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.52; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.40\u20138.49), proximal serrated polyps (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.23, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.38\u20133.60), large serrated polyps (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 59.25; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 18.85\u2013186.21), hyperplastic polyps (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.66; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.03\u20132.67), three or more serrated polyps (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.86; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.24\u201319.15) and one or more non\u2010advanced tubular adenomas (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.58, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.59\u20134.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Detection of proximal, sessile and\/or large serrated polyps at screening colonoscopy is independently associated with an increased risk for synchronous advanced neoplasia<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13003","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:46:47Z","timestamp":1414025207000},"page":"108-115","source":"Crossref","is-referenced-by-count":44,"title":["Association between serrated polyps and the risk of synchronous advanced colorectal neoplasia in average\u2010risk individuals"],"prefix":"10.1111","volume":"41","author":[{"given":"S. C.","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Y. L.","family":"Ching","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. C. W.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C. S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"},{"name":"Faculty of Medicine School of Public Health and Primary Care Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K. C.","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Y. T.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W. H.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C. Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. K. L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Institute of Digestive Disease Li Ka Shing Institute of Health Science State Key Laboratory of Digestive Diseases Chinese University of Hong Kong Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Y. W.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Surgery Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J. 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