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Magnetic resonance enterography (\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      ) has emerged as a non\u2010invasive means of monitoring inflammation and damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      As part of the development of\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      \u2010based multi\u2010item measures of inflammation and damage for paediatric studies, we carried out a systematic review and meta\u2010analysis to identify\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      variables used to describe these two distinct concepts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      2501 studies of\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      were identified. Studies written in any language reporting individual\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      signs for patients diagnosed with\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      were included. Two\u2010hundred\u2010and\u2010forty\u2010four studies were fully reviewed and 62 were included (inflammation,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a051; damage,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a024). Sensitivity, specificity and associated confidence intervals were calculated, and hierarchical summary\n                      <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>\n                      curves were constructed for each\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      sign.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 22\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      signs were used to reflect inflammation, and 9 to reflect damage. Diagnostic accuracy of\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      signs of inflammation and damage was heterogeneous; however, wall enhancement, mucosal lesions and wall T2 hyperintensity were the most consistently useful for inflammation (most sensitivities &gt;80% and specificities &gt;90%), and detection of abscess and fistula were most consistently useful for damage (most sensitivities &gt;90%, specificities &gt;95%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Identifying the best\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      variables to reflect inflammation and damage will maximise the utility of this rapidly emerging technique and is the first stage of constructing\n                      <jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>\n                      \u2010based indices for evaluating inflammation and intestinal damage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.13024","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T05:21:25Z","timestamp":1416288085000},"page":"153-166","source":"Crossref","is-referenced-by-count":75,"title":["Systematic review with meta\u2010analysis: magnetic resonance enterography signs for the detection of inflammation and intestinal damage in Crohn's disease"],"prefix":"10.1111","volume":"41","author":[{"given":"P. C.","family":"Church","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition The Hospital for Sick Children Department of Paediatrics University of Toronto Toronto Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Turner","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition Shaare Zedek Medical Center The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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