{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:36:37Z","timestamp":1769571397161,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of antiviral therapy on the post\u2010hepatectomy long\u2010term survival in patients with hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>)\u2010related hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effect of antiviral therapy on post\u2010hepatectomy survival and recurrence in patients with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective\u2010retrospective study of a total of 404 patients who underwent hepatectomy for <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> in a tertiary academic hospital. Data on patient and tumour characteristics, tumour recurrence, treatment for recurrence and survival were compared between antiviral and no antiviral groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient's and tumour characteristics were comparable between the two groups, except a higher proportion of patients with cirrhosis in the antiviral group. With a mean follow\u2010up time of 52.4\u00a0months, antiviral group had a better 5\u2010year overall survival (66.7% vs. 56.0%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.001) while there was no significant difference in the 5\u2010year disease\u2010free survival (44.7% vs. 38.1%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.166). Use of antiviral therapy was associated with better liver function reserve at the time of recurrence and a greater proportion of patients could receive curative treatment for recurrence (38.5% vs. 24.3%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.041). There was no significant different in the hazard ratios of patients who started antiviral therapy before or after operation (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.054).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of antiviral therapy improves the long\u2010term post\u2010hepatectomy survival in patients with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>. With a better liver function reserve at the time of recurrence, a greater proportion of patients in antiviral group could receive curative treatment for recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13034","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T10:26:05Z","timestamp":1416565565000},"page":"199-208","source":"Crossref","is-referenced-by-count":52,"title":["Antiviral therapy improves post\u2010hepatectomy survival in patients with hepatitis B virus\u2010related hepatocellular carcinoma: a prospective\u2010retrospective study"],"prefix":"10.1111","volume":"41","author":[{"given":"C. C. N.","family":"Chong","sequence":"first","affiliation":[{"name":"Division of Hepato\u2010biliary and Pancreatic Surgery Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. L. 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