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<jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To determine the relationship between resolution of\n                      <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>\n                      and dyslipidemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Individuals in the Pioglitazone vs.\n                      <jats:italic>V<\/jats:italic>\n                      itamin\n                      <jats:italic>E<\/jats:italic>\n                      vs. Placebo for the Treatment of Nondiabetic Patients with\n                      <jats:italic>N<\/jats:italic>\n                      onalcoholic\n                      <jats:italic>S<\/jats:italic>\n                      teatohepatitis (\n                      <jats:styled-content style=\"fixed-case\">PIVENS<\/jats:styled-content>\n                      ) trial with paired liver biopsies and fasting lipid levels were included (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0222). In the\n                      <jats:styled-content style=\"fixed-case\">PIVENS<\/jats:styled-content>\n                      trial individuals were randomised to pioglitazone 30\u00a0mg, vitamin E 800\u00a0IU or placebo for 96\u00a0weeks. Change in lipid levels at 96\u00a0weeks was compared between those with and without\n                      <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>\n                      resolution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dyslipidemia at baseline was frequent, with low high\u2010density lipoprotein (HDL) (&lt;40\u00a0mg\/dL in men or &lt;50\u00a0mg\/dL in women) in 63%, hypertriglyceridaemia (\u2265150\u00a0mg\/dL) in 46%, hypercholesterolaemia (\u2265200\u00a0mg\/dL) in 47% and triglycerides (TG)\/HDL &gt;5.0 in 25%. Low\u2010density lipoprotein (LD) \u2265160\u00a0mg\/dL was found in 16% and elevated non\u2010HDL cholesterol (non\u2010HDL\u2010C) (\u2265130\u00a0mg\/dL) in 73%. HDL increased with NASH resolution but decreased in those without resolution (2.9\u00a0mg\/dL vs. \u22122.5\u00a0mg\/dL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). NASH resolution was associated with significant decreases in TG and TG\/HDL ratio compared to those without resolution (TG: \u221221.1 vs. \u22122.3\u00a0mg\/dL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03 and TG\/HDL: \u22120.7 vs. 0.1,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003). Non\u2010HDL\u2010C, LDL and cholesterol decreased over 96\u00a0weeks in both groups, but there was no significant difference between groups. Treatment group did not impact lipids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>\n                      resolution is associated with improvements in\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                      but not in other\n                      <jats:styled-content style=\"fixed-case\">cardiovascular disease<\/jats:styled-content>\n                      risk factors including\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      and non\u2010\n                      <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                      \u2010C levels. Individuals with resolution of\n                      <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>\n                      may still be at increased risk of\n                      <jats:styled-content style=\"fixed-case\">cardiovascular disease<\/jats:styled-content>\n                      .\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier:\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      00063622.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.13035","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T11:55:05Z","timestamp":1417175705000},"page":"301-309","source":"Crossref","is-referenced-by-count":53,"title":["<scp>NASH<\/scp>\n                    resolution is associated with improvements in\n                    <scp>HDL<\/scp>\n                    and triglyceride levels but not improvement in\n                    <scp>LDL<\/scp>\n                    or non\u2010\n                    <scp>HDL<\/scp>\n                    \u2010C levels"],"prefix":"10.1111","volume":"41","author":[{"given":"K. 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