{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:15:14Z","timestamp":1783026914842,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Results are conflicting with respect to the renal effects of anti\u2010viral agents used for <jats:styled-content style=\"fixed-case\">hepatitis B virus<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare short and long\u2010term renal effects in real\u2010life settings and to determine risk factors for renal impairment during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>2221 treatment\u2010na\u00efve patients were enrolled. Among these, 895 (302 lamivudine, 27 telbivudine, 282 entecavir, 273 tenofovir and 11 adefovir initiated patients) had \u2018repeated measures\u2019 of creatinine (baseline, 1st, 6th, 12th and 24th month of treatment). Telbivudine and adefovir groups were excluded from further analysis because of the low number of patients. We calculated the glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) using the Modification of Diet in Renal Disease (<jats:styled-content style=\"fixed-case\">MDRD<\/jats:styled-content>) formula at each time point. Hypophosphataemia was also recorded. Risk factors for renal impairment were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tenofovir caused a decline in GFR at each time point when compared to baseline levels. However, lamivudine and entecavir did not change GFR. GFR\u2010shifting from \u226590 to 60\u201389\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> was comparable among groups. The proportion of patients whose baseline creatinine increased more than 25% was comparable among all anti\u2010virals. GFR showed a decline in patients who switched from entecavir to tenofovir. One patient with compensated cirrhosis needed to change from tenofovir because of renal safety. Seven and three patients developed transient hypophosphataemia in the tenofovir and lamivudine groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although tenofovir caused a decline in <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>, differences between the anti\u2010viral agents do not appear to be so impressive. In patients with and without renal risk factors at baseline, there is no impact of anti\u2010virals, including tenofovir.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13036","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T07:06:44Z","timestamp":1417763204000},"page":"310-319","source":"Crossref","is-referenced-by-count":43,"title":["Differences in nephrotoxicity risk and renal effects among anti\u2010viral therapies against hepatitis B"],"prefix":"10.1111","volume":"41","author":[{"given":"S.","family":"Koklu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hacettepe University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Gulsen","sequence":"additional","affiliation":[{"name":"Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tuna","sequence":"additional","affiliation":[{"name":"Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Koklu","sequence":"additional","affiliation":[{"name":"Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Demir","sequence":"additional","affiliation":[{"name":"Hatay Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Guner","sequence":"additional","affiliation":[{"name":"Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Dogan","sequence":"additional","affiliation":[{"name":"Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kucukazman","sequence":"additional","affiliation":[{"name":"Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. K.","family":"Poyrazoglu","sequence":"additional","affiliation":[{"name":"Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Biyik","sequence":"additional","affiliation":[{"name":"Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Aydogan","sequence":"additional","affiliation":[{"name":"Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Coban","sequence":"additional","affiliation":[{"name":"Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Kocaman","sequence":"additional","affiliation":[{"name":"Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sapmaz","sequence":"additional","affiliation":[{"name":"Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Gokturk","sequence":"additional","affiliation":[{"name":"Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Karaca","sequence":"additional","affiliation":[{"name":"Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Demirezer","sequence":"additional","affiliation":[{"name":"Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tanoglu","sequence":"additional","affiliation":[{"name":"Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Altinbas","sequence":"additional","affiliation":[{"name":"Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M.","family":"Atak","sequence":"additional","affiliation":[{"name":"Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Cosar","sequence":"additional","affiliation":[{"name":"Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Alkan","sequence":"additional","affiliation":[{"name":"Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Other collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23044"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01160.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06852.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0779-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2269-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05093.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.031"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis937"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12088"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60544-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(13)60746-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2649"},{"key":"e_1_2_7_15_1","first-page":"342","article-title":"Tenofovir\u2010associated Fanconi syndrome in a patient with chronic hepatitis B","volume":"23","author":"Samarkos M","year":"2014","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_7_16_1","first-page":"S265","article-title":"Renal function under telbivudine monotherapy in a real\u2010life multicenter observational study\u2010the FRESH study","volume":"7","author":"Mimidis K","year":"2013","journal-title":"Hepatol Int"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.11.028"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/428840"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328351f68f"},{"key":"e_1_2_7_20_1","unstructured":"LamperticoP ViganoM YurtaydinC et\u00a0al.Effectiveness and safety of tenofovir disoproxil fumarate in field practice: a multicenter European cohort study of 737 patients with chronic hepatitis B. 61th Annual meeting of the American Association of fort he Study of Liver Diseases (AASLD) October 29\u2013November 2 2010 Boston MA."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.07.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.03.030"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.04.008"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12538"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12499"},{"key":"e_1_2_7_27_1","article-title":"Hypophosphatemic osteomalacia induced by tenofovir in HIV\u2010infected patients","author":"Mateo L","year":"2014","journal-title":"Clin Rheumatol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:40:16Z","timestamp":1695552016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,4]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/apt.13036"],"URL":"https:\/\/doi.org\/10.1111\/apt.13036","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,4]]}}}