{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T16:30:44Z","timestamp":1780763444059,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,11]],"date-time":"2015-01-11T00:00:00Z","timestamp":1420934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear whether the course of cirrhosis and its prognosis are related to the amount of collagen in the liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine whether fibrosis, assessed by collagen proportionate area (<jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>) in patients with compensated cirrhosis, is associated with the presence of oesophageal varices, and predict disease decompensation during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively evaluated 118 consecutive patients with compensated cirrhosis to correlate fibrosis, assessed by <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> in liver biopsies, with the presence of oesophageal varices (<jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>) and with the rate of liver decompensation (<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>) development during a median follow\u2010up of 72\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline 38 (32.2%) patients had <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> and during the follow\u2010up (median 72\u00a0months, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 47\u201391), 17 patients (14.4%) developed <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>. The mean <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> value was different in patients with and without <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> (14.8\u00a0\u00b1\u00a05.9% vs. 21.6\u00a0\u00b1\u00a09.5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The best <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> cut\u2010off for <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> by area under the receiver operating characteristic (<jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>) was \u226514% and with multivariate logistic analysis <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> was the only variable associated with <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 28.32, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 6.30\u2013127.28; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). By <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content> analysis the best <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> cut\u2010off to predict <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content> was 18.0%. By Cox regression multivariate analysis <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> \u226518% (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: 3.99, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.04\u201311.45; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.036), albumin (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: 0.12, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.04\u20130.43; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and presence of <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: 8.15, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.31\u201328.78; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) were independently associated with <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Quantification of fibrosis by <jats:styled-content style=\"fixed-case\">collagen proportionate area<\/jats:styled-content> allows identification of patients with compensated <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> cirrhosis with a higher likelihood of clinically relevant portal hypertension and a higher risk of decompensation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13051","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T01:30:52Z","timestamp":1421026252000},"page":"477-486","source":"Crossref","is-referenced-by-count":23,"title":["Quantification of fibrosis by collagen proportionate area predicts hepatic decompensation in hepatitis C cirrhosis"],"prefix":"10.1111","volume":"41","author":[{"given":"V.","family":"Calvaruso","sequence":"first","affiliation":[{"name":"Sezione di Gastroenterologia e Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.) University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia e Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.) University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"Bavetta","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia e Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.) University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cabibi","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia Patologica Policlinico Paolo Giaccone University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Conte","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia e Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.) University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bronte","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia e Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.) University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Simone","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia e Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.) University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Burroughs","sequence":"additional","affiliation":[{"name":"The Royal Free Sheila Sherlock Liver Centre and Institute of Liver and Digestive Health UCL Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Crax\u00ec","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia e Epatologia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.) 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