{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:29Z","timestamp":1792787009979,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:00:00Z","timestamp":1418947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Appel d'offre Charles Nicolle - Fondation Charles Nicolle","award":["2008\/163\/HP"],"award-info":[{"award-number":["2008\/163\/HP"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n Pyloric pressure and compliance have never been investigated in health nor gastroparesis.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n We hypothesised that pyloric pressure and\/or compliance may be altered in gastroparesis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fasting pyloric pressure and compliance were investigated in 21 healthy volunteers (\n HV<\/jats:styled-content>\n ), 27 gastroparetic patients (\n GP<\/jats:styled-content>\n ) and 5 patients who had undergone oesophagectomy without pyloroplasty as positive controls. Under videofluoroscopic control, pyloric compliance and pressure were measured by the Endo\n FLIP<\/jats:styled-content>\n technique. Gastric emptying half time (\n T<\/jats:italic>\n 1\/2<\/jats:sub>\n ) using\n 13<\/jats:sup>\n C\u2013octanoic acid breath test, as well as symptoms and quality of life (\n GIQLI<\/jats:styled-content>\n score) were also monitored.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean fasting pyloric compliance was measured at 25.2\u00a0\u00b1\u00a02.4\u00a0mm\u00b2\/mmHg in\n HV<\/jats:styled-content>\n , and was lower both in\n GP<\/jats:styled-content>\n (16.9\u00a0\u00b1\u00a02.1\u00a0mm\u00b2\/mmHg;\n P<\/jats:italic>\n \u00a0<\u00a00.05) and patients with oesophagectomy (10.9\u00a0\u00b1\u00a02.9\u00a0mm\u00b2\/mmHg;\n P<\/jats:italic>\n \u00a0<\u00a00.05). By contrast, fasting pyloric pressure was not different among groups. Fasting pyloric compliance and pressure correlated with\n T<\/jats:italic>\n 1\/2<\/jats:sub>\n in\n GP<\/jats:styled-content>\n (\n R<\/jats:italic>\n \u00a0=\u00a0\u22120.43;\n P<\/jats:italic>\n \u00a0=\u00a00.04). Fasting pyloric compliance, but not pressure, correlated with symptoms and\n GIQLI<\/jats:styled-content>\n score. Pyloric dilation in 10\n GP<\/jats:styled-content>\n with low fasting pyloric compliance (<10\u00a0mm\u00b2\/mmHg) increased compliance from 7.4\u00a0\u00b1\u00a00.4 to 20.1\u00a0\u00b1\u00a04.9\u00a0mm\u00b2\/mmHg (\n P<\/jats:italic>\n \u00a0<\u00a00.01) and improved the\n GIQLI<\/jats:styled-content>\n score from 72.5\u00a0\u00b1\u00a05.5 to 89.3\u00a0\u00b1\u00a06.1 (\n P<\/jats:italic>\n \u00a0=\u00a00.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This prospective study assessed pyloric compliance for the first time, and showed that fasting pyloric compliance is decreased in\n gastroparetic patients<\/jats:styled-content>\n and is associated with\n T<\/jats:italic>\n 1\/2<\/jats:sub>\n , symptoms and quality of life. This suggests that pyloric compliance may be a new relevant metric in\n gastroparetic patients,<\/jats:styled-content>\n and may be useful to target patients for pyloric dilation or botulinum toxin injection.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.13053","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:21:09Z","timestamp":1418970069000},"page":"360-367","source":"Crossref","is-referenced-by-count":178,"title":["Impaired fasting pyloric compliance in gastroparesis and the therapeutic response to pyloric dilatation"],"prefix":"10.1111","volume":"41","author":[{"given":"G.","family":"Gourcerol","sequence":"first","affiliation":[{"name":"Physiology Department Rouen University Hospital Rouen France"},{"name":"Nutrition, Brain and Gut Laboratory INSERM unit 1073 Rouen University Hospital Rouen France"},{"name":"Clinical Investigation Center INSERM 0204 Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tissier","sequence":"additional","affiliation":[{"name":"Physiology Department Rouen University Hospital Rouen France"},{"name":"Hepatogastroenterology Department Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Melchior","sequence":"additional","affiliation":[{"name":"Physiology Department Rouen University Hospital Rouen France"},{"name":"Nutrition, Brain and Gut Laboratory INSERM unit 1073 Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Y.","family":"Touchais","sequence":"additional","affiliation":[{"name":"Physiology Department Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Huet","sequence":"additional","affiliation":[{"name":"Nutrition, Brain and Gut Laboratory INSERM unit 1073 Rouen University Hospital Rouen France"},{"name":"Surgery Department Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Prevost","sequence":"additional","affiliation":[{"name":"Diabetology Department INSERM unit 982 Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Leroi","sequence":"additional","affiliation":[{"name":"Physiology Department Rouen University Hospital Rouen France"},{"name":"Nutrition, Brain and Gut Laboratory INSERM unit 1073 Rouen University Hospital Rouen France"},{"name":"Clinical Investigation Center INSERM 0204 Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ducrotte","sequence":"additional","affiliation":[{"name":"Physiology Department Rouen University Hospital Rouen France"},{"name":"Nutrition, Brain and Gut Laboratory INSERM unit 1073 Rouen University Hospital Rouen France"},{"name":"Hepatogastroenterology Department Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.055"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.047"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026665728213"},{"key":"e_1_2_9_5_1","first-page":"G580","article-title":"Relation between antral motility and gastric emptying of solids and liquids in humans","volume":"249","author":"Camilleri M","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90444-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1984.tb01206.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90578-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90010-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90262-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03467.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01676.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.048"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820229"},{"key":"e_1_2_9_15_1","first-page":"25","article-title":"First validation of the French version of the Gastrointestinal Quality of Life Index (GIQLI)","volume":"23","author":"Slim K","year":"1999","journal-title":"Gastroenterol Clin Biol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90640-X"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12181"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.01.013"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34374"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80199-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00866.x"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13053","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:13:25Z","timestamp":1696515205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,19]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/apt.13053"],"URL":"https:\/\/doi.org\/10.1111\/apt.13053","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,19]]}}}