{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:01:00Z","timestamp":1789682460369,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have shown that weight changes are common in patients with coeliac disease after starting a gluten\u2010free diet (GFD), but data on the prevalence of metabolic syndrome in this population are still scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the prevalence of metabolic syndrome in patients with CD at diagnosis and 1\u00a0year after starting GFD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled all consecutive patients with newly diagnosed coeliac disease (CD) who were referred to our third\u2010level CD Unit. For all patients we collected: waist circumference, BMI, blood pressure, lipid profile (HDL cholesterol, triglycerides) and levels of blood glucose. Diagnosis of metabolic syndrome was made according to the International Diabetes Federation (IDF) criteria for European countries. The prevalence of metabolic syndrome was re\u2010assessed after 12\u00a0months of GFD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010eight patients with CD were assessed, two patients with CD (2%) fulfilled the diagnostic criteria for metabolic syndrome at diagnosis and 29 patients (29.5%) after 12\u00a0months of GFD (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; OR: 20). With regard to metabolic syndrome sub\u2010categories 1\u00a0year after GFD compared to baseline respectively: 72 vs. 48 patients exceeded waist circumference cut\u2010off (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01; OR: 2.8); 18 vs. 4 patients had high blood pressure (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; OR: 5.2); 25 vs. 7 patients exceeded glycemic threshold (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01; OR: 4.4); 34 vs. 32 patients with CD had reduced levels of HDL cholesterol (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.7); and 16 vs. 7 patients had high levels of triglycerides (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with coeliac disease show a high risk of metabolic syndrome 1\u00a0year after starting a gluten\u2010free diet. We suggest that an in\u2010depth nutritional assessment is undertaken for all patients with coeliac disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13062","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T07:28:43Z","timestamp":1420702123000},"page":"352-359","source":"Crossref","is-referenced-by-count":149,"title":["Metabolic syndrome in patients with coeliac disease on a gluten\u2010free diet"],"prefix":"10.1111","volume":"41","author":[{"given":"R.","family":"Tortora","sequence":"first","affiliation":[{"name":"Gastroenterology \u2013 Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Capone","sequence":"additional","affiliation":[{"name":"Gastroenterology \u2013 Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Gastroenterology \u2013 Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Imperatore","sequence":"additional","affiliation":[{"name":"Gastroenterology \u2013 Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Gerbino","sequence":"additional","affiliation":[{"name":"Gastroenterology \u2013 Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Donetto","sequence":"additional","affiliation":[{"name":"Department of Education and Professional Studies King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Monaco","sequence":"additional","affiliation":[{"name":"Gastroenterology \u2013 Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Caporaso","sequence":"additional","affiliation":[{"name":"Gastroenterology \u2013 Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rispo","sequence":"additional","affiliation":[{"name":"Gastroenterology \u2013 Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.02.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199607000-00007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.07.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7168.1290"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60254-3"},{"key":"e_1_2_7_9_1","first-page":"909","article-title":"Revised criteria for diagnosis of coeliac disease. 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