{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:05:39Z","timestamp":1790877939060,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK92179"],"award-info":[{"award-number":["R01-DK92179"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1-TR000135 CCaTS grant"],"award-info":[{"award-number":["UL1-TR000135 CCaTS grant"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      About one\u2010third of patients with\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      \u2010diarrhoea (irritable bowel syndrome\u2010D) have evidence of increased bile acid synthesis or excretion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To assess effects of the\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      sequestrant, colesevelam, on faecal excretion of\n                      <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n                      s, hepatic\n                      <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n                      synthesis and diarrhoea in\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      \u2010D; to appraise whether individual or random stool samples accurately reflect 48\u2010h total faecal\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      excretion and proportions of the main\n                      <jats:styled-content style=\"fixed-case\">bile acids<\/jats:styled-content>\n                      excreted and to study the faecal fat excretion in response to colesevelam.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010centre, unblinded, single\u2010dose trial of effects of colesevelam, 1875\u00a0mg [3 tablets (625\u00a0mg tablets)] orally, twice daily, for 10\u00a0days on total 48\u2010h faecal\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      excretion and fasting serum C4 (7\u03b1\u2010hydroxy\u20104\u2010cholesten\u20103\u2010one; surrogate of hepatic\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      synthesis). Stool diaries documented bowel functions for 8\u00a0days prior and 8\u00a0days during colesevelam treatment. Stool 48\u2010h samples and fasting serum were collected for faecal fat, faecal\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      and serum C4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Colesevelam was associated with significantly increased faecal total\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      excretion and deoxycholic acid excretion, increased serum C4 and more solid stool consistency. There was a significant inverse correlation between number of bowel movements per week and the total\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      sequestered into stool during the last 48\u00a0h of treatment. Random stool samples did not accurately reflect 48\u2010h total or individual faecal\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      excretion. Sequestration of\n                      <jats:styled-content style=\"fixed-case\">bile acids<\/jats:styled-content>\n                      by colesevelam did not increase faecal fat.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Colesevelam increases delivery of\n                      <jats:styled-content style=\"fixed-case\">bile acids<\/jats:styled-content>\n                      to stool while improving stool consistency, and increases hepatic\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      synthesis, avoiding steatorrhoea in patients with\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      \u2010D. Overall effects are consistent with luminal\n                      <jats:styled-content style=\"fixed-case\">bile acid<\/jats:styled-content>\n                      sequestration by colesevelam.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.13065","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T04:20:50Z","timestamp":1421382050000},"page":"438-448","source":"Crossref","is-referenced-by-count":106,"title":["Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea\u2010predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"41","author":[{"given":"M.","family":"Camilleri","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Acosta","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Busciglio","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boldingh","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) 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