{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:05:31Z","timestamp":1789704331068,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":230,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"European Helicobacter Study Group"},{"name":"Instituto Carlos III"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1111\/apt.13069","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T15:29:01Z","timestamp":1421249341000},"page":"581-589","source":"Crossref","is-referenced-by-count":81,"title":["Optimised empiric triple and concomitant therapy for<i>Helicobacter pylori<\/i>eradication in clinical practice: the OPTRICON study"],"prefix":"10.1111","volume":"41","author":[{"given":"J.","family":"Molina-Infante","sequence":"first","affiliation":[{"name":"Department of Gastroenterology; Hospital San Pedro de Alcantara; Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Hospital General; Tomelloso Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Angueira","sequence":"additional","affiliation":[{"name":"Hospital General; Tomelloso Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rodriguez-Tellez","sequence":"additional","affiliation":[{"name":"Hospital Virgen Macarena; Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Perez-Aisa","sequence":"additional","affiliation":[{"name":"Agencia Sanitaria Costa del Sol; Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Balboa","sequence":"additional","affiliation":[{"name":"Clinica Teknon; Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Barrio","sequence":"additional","affiliation":[{"name":"Hospital Rio Hortega; Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Martin-Noguerol","sequence":"additional","affiliation":[{"name":"Hospital Carmen y Severo Ochoa; Cangas del Narcea Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Gomez-Rodriguez","sequence":"additional","affiliation":[{"name":"Hospital Sagrado Corazon; Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Botargues-Bote","sequence":"additional","affiliation":[{"name":"Hospital Bellvitge; Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gomez-Camarero","sequence":"additional","affiliation":[{"name":"Hospital Gregorio Mara\u00f1on; Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Huerta","sequence":"additional","affiliation":[{"name":"HM Sanchinarro; Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Modolell","sequence":"additional","affiliation":[{"name":"Consorci Sanitari; Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ari\u00f1o","sequence":"additional","affiliation":[{"name":"HCU Lozano Blesa and CIBEREHD; Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Herranz-Bachiller","sequence":"additional","affiliation":[{"name":"Hospital de Fuenlabrada; Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Hospital de Fuenlabrada; Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"McNicholl","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa; IP and CIBEREHD; Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"O'Morain","sequence":"additional","affiliation":[{"name":"Adelaide and Meath Hospital incorporating the National Children's Hospital\/Trinity College; Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"J. P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa; IP and CIBEREHD; Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the European Registry on H. pylori management (Hp-EuReg)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"10.1111\/apt.13069-BIB0001|apt13069-cit-0001","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1111\/j.1572-0241.2007.01393.x","article-title":"American College of Gastroenterology Guideline on the management of Helicobacter Pylori infection","volume":"102","author":"Chey","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/apt.13069-BIB0002|apt13069-cit-0002","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/gut.2006.101634","article-title":"Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report","volume":"56","author":"Malfertheiner","year":"2007","journal-title":"Gut"},{"key":"10.1111\/apt.13069-BIB0003|apt13069-cit-0003","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/j.1440-1746.2009.05982.x","article-title":"Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection","volume":"24","author":"Fock","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/apt.13069-BIB0004|apt13069-cit-0004","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/gutjnl-2012-302254","article-title":"Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption","volume":"62","author":"Megraud","year":"2013","journal-title":"Gut"},{"key":"10.1111\/apt.13069-BIB0005|apt13069-cit-0005","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1136\/gut.2009.192757","article-title":"Helicobacter pylori treatment in the era of increasing antibiotic resistance","volume":"59","author":"Graham","year":"2010","journal-title":"Gut"},{"key":"10.1111\/apt.13069-BIB0006|apt13069-cit-0006","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cgh.2013.05.028","article-title":"Rational Helicobacter pylori therapy: evidence based medicine rather than medicine based evidence","volume":"12","author":"Graham","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/apt.13069-BIB0007|apt13069-cit-0007","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gutjnl-2012-302084","article-title":"Management of Helicobacter pylori infection-the Maastricht IV\/ Florence Consensus Report","volume":"61","author":"Malfertheiner","year":"2012","journal-title":"Gut"},{"key":"10.1111\/apt.13069-BIB0008|apt13069-cit-0008","doi-asserted-by":"crossref","first-page":"923","DOI":"10.7326\/0003-4819-148-12-200806170-00226","article-title":"Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatment","volume":"148","author":"Jafri","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1111\/apt.13069-BIB0009|apt13069-cit-0009","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2710.2008.00969.x","article-title":"Sequential therapy vs. standard triple therapies for Helicobacter pylori infection: a meta-analysis","volume":"34","author":"Tong","year":"2009","journal-title":"J Clin Pharm Ther"},{"key":"10.1111\/apt.13069-BIB0010|apt13069-cit-0010","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1038\/ajg.2009.555","article-title":"Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children","volume":"104","author":"Gatta","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/apt.13069-BIB0011|apt13069-cit-0011","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1523-5378.2009.00671.x","article-title":"Meta-analysis: four-drug, three-antibiotic, non-bismuth-containing \u201cconcomitant therapy\u201d versus triple therapy for Helicobacter pylori eradication","volume":"14","author":"Essa","year":"2009","journal-title":"Helicobacter"},{"key":"10.1111\/apt.13069-BIB0012|apt13069-cit-0012","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2147\/CEG.S25419","article-title":"Update on non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori","volume":"5","author":"Gisbert","year":"2012","journal-title":"Clin Exp Gastroenterol"},{"key":"10.1111\/apt.13069-BIB0013|apt13069-cit-0013","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1365-2036.2012.05229.x","article-title":"Meta-analysis: sequential therapy for Helicobacter pylori eradication in children","volume":"36","author":"Horvath","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13069-BIB0014|apt13069-cit-0014","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejim.2012.07.006","article-title":"Standard triple and sequential therapies for Helicobacter pylori eradication: an update","volume":"24","author":"Zullo","year":"2013","journal-title":"Eur J Intern Med"},{"key":"10.1111\/apt.13069-BIB0015|apt13069-cit-0015","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s40265-013-0053-z","article-title":"Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a systematic review of recent evidence","volume":"73","author":"Kate","year":"2013","journal-title":"Drugs"},{"key":"10.1111\/apt.13069-BIB0016|apt13069-cit-0016","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/jgh.12397","article-title":"Meta-analysis: is sequential therapy superior to standard triple therapy for Helicobacter pylori infection in Asian adults?","volume":"28","author":"Yoon","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/apt.13069-BIB0017|apt13069-cit-0017","doi-asserted-by":"crossref","first-page":"546","DOI":"10.5009\/gnl.2013.7.5.546","article-title":"Sequential therapy for helicobacter pylori infection in Korea: systematic review and meta-analysis","volume":"7","author":"Kim","year":"2013","journal-title":"Gut Liv"},{"issue":"Suppl 1","key":"10.1111\/apt.13069-BIB0018|apt13069-cit-0018","first-page":"S","article-title":"Meta-analysis of sequential vs. standard triple therapy for Helicobacter pylori eradication: final results of a Cochrane systematic review","volume":"146","author":"Nyssen","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.13069-BIB0019|apt13069-cit-0019","doi-asserted-by":"crossref","first-page":"f4587","DOI":"10.1136\/bmj.f4587","article-title":"Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy","volume":"347","author":"Gatta","year":"2013","journal-title":"BMJ"},{"issue":"1","key":"10.1111\/apt.13069-BIB0020|apt13069-cit-0020","first-page":"129","article-title":"Meta-analysis of sequential vs. standard triple therapy for Helicobacter pylori eradication: final results of a Cochrane systematic review","volume":"19","author":"Nyssen","year":"2014","journal-title":"Helicobacter"},{"key":"10.1111\/apt.13069-BIB0021|apt13069-cit-0021","first-page":"S","article-title":"Sequential therapy is not better at eradication of primary Helicobacter pylori infection when compared to standard triple therapy in the United States-a prospective, randomized evaluation in a United States population","volume":"1","author":"Cross","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.13069-BIB0022|apt13069-cit-0022","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1523-5378.2011.00911.x","article-title":"Evaluation of a four-drug, three-antibiotic, nonbismuth-containing \u201cconcomitant\u201d therapy as first-line Helicobacter pylori eradication regimen in Greece","volume":"17","author":"Georgopoulos","year":"2012","journal-title":"Helicobacter"},{"key":"10.1111\/apt.13069-BIB0023|apt13069-cit-0023","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.gastro.2013.03.050","article-title":"Optimized nonbismuth quadruple therapies cure most patients with Helicobacter pylori infection in populations with high rates of antibiotic resistance","volume":"145","author":"Molina-Infante","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.13069-BIB0024|apt13069-cit-0024","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/hel.12062","article-title":"Clinical evaluation of a ten-day regimen with esomeprazole, metronidazole, amoxicillin, and clarithromycin for the eradication of Helicobacter pylori in a high clarithromycin resistance area","volume":"18","author":"Georgopoulos","year":"2013","journal-title":"Helicobacter"},{"key":"10.1111\/apt.13069-BIB0025|apt13069-cit-0025","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/gutjnl-2013-304820","article-title":"Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine clinical practice","volume":"63","author":"McNicholl","year":"2014","journal-title":"Gut"},{"key":"10.1111\/apt.13069-BIB0026|apt13069-cit-0026","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.gastrohep.2013.01.011","article-title":"III Spanish consensus conference on Helicobacter pylori infection","volume":"36","author":"Gisbert","year":"2013","journal-title":"Gastroenterol Hepatol"},{"key":"10.1111\/apt.13069-BIB0027|apt13069-cit-0027","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1365-2036.2012.05211.x","article-title":"Meta-analysis: esomeprazole or rabeprazole vs. first-generation pump inhibitors in the treatment of Helicobacter pylori infection","volume":"36","author":"McNicholl","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13069-BIB0028|apt13069-cit-0028","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/apt.12492","article-title":"Twice-daily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolisers compared with twice-daily omeprazole, rabeprazole or lansoprazole","volume":"38","author":"Sahara","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13069-BIB0029|apt13069-cit-0029","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1365-2036.2012.05137.x","article-title":"High-dose, ten-day esomeprazole, amoxicillin and metronidazole triple therapy achieves high Helicobacter pylori eradication rates","volume":"36","author":"S\u00e1nchez-Delgado","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13069-BIB0030|apt13069-cit-0030","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/apt.12329","article-title":"Pilot study: miscellaneous therapy is highly successful for Helicobacter pylori eradication","volume":"37","author":"Sierra","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13069-BIB0031|apt13069-cit-0031","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.gastrohep.2013.02.006","article-title":"Update on the efficacy of triple therapy for Helicobacter pylori infection and clarithromycin resistance rates in Spain (2007-2012)","volume":"36","author":"Molina-Infante","year":"2013","journal-title":"Gastroenterol Hepatol"},{"key":"10.1111\/apt.13069-BIB0032|apt13069-cit-0032","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0140-6736(12)61579-7","article-title":"Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial","volume":"381","author":"Liou","year":"2013","journal-title":"Lancet"},{"key":"10.1111\/apt.13069-BIB0033|apt13069-cit-0033","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1053\/j.gastro.2013.07.054","article-title":"Is there a nonbismuth quadruple therapy that can reliably overcome bacterial resistance?","volume":"145","author":"Georgopoulos","year":"2013","journal-title":"Gastroenterology"},{"issue":"Suppl 1","key":"10.1111\/apt.13069-BIB0034|apt13069-cit-0034","first-page":"S","article-title":"Sequential and Concomitant Treatments in H. pylori Eradication: a Network Meta-Analysis","volume":"146","author":"McNicholl","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.13069-BIB0035|apt13069-cit-0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1523-5378.2012.00947.x","article-title":"Non-bismuth quadruple (concomitant) therapy: empiric and tailored efficacy vs. standard triple therapy for clarithromycin-susceptible Helicobacter pylori and vs. sequential therapy for clarithromycin-resistant strains","volume":"17","author":"Molina-Infante","year":"2012","journal-title":"Helicobacter"},{"issue":"Suppl. 1","key":"10.1111\/apt.13069-BIB0036|apt13069-cit-0036","first-page":"S","article-title":"Non-Bismuth Quadruple (Concomitant) Therapy for Eradication of H. pylori: standard vs. Optimized (14-Day, High-Dose PPI) Regimen","author":"Gisbert","year":"2014","journal-title":"Gastroenterology"},{"issue":"Suppl 1","key":"10.1111\/apt.13069-BIB0037|apt13069-cit-0037","first-page":"80","article-title":"A randomised study comparing 10 days concomitant and sequential treatments for the eradication of Helicobacter pylori, in a high clarithromycin resistance area","volume":"19","author":"Georgopoulos","year":"2014","journal-title":"Helicobacter"},{"key":"10.1111\/apt.13069-BIB0038|apt13069-cit-0038","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1365-2036.2011.04944.x","article-title":"Letter: the ethics of using inferior regimens in H. pylori randomised trials","volume":"35","author":"Graham","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13069-BIB0039|apt13069-cit-0039","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1365-2036.2011.04887.x","article-title":"Review article: the effectiveness of standard triple therapy for Helicobacter pylori has not changed over the last decade, but it is not good enough","volume":"34","author":"Gisbert","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13069-BIB0040|apt13069-cit-0040","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.2169\/internalmedicine.50.5135","article-title":"Is culture necessary before first-line treatment for Helicobacter pylori infection?","volume":"50","author":"Gisbert","year":"2011","journal-title":"Intern Med"},{"key":"10.1111\/apt.13069-BIB0041|apt13069-cit-0041","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0140-6736(11)60020-2","article-title":"Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, openlabel, non-inferiority, phase 3 trial","volume":"377","author":"Malfertheiner","year":"2011","journal-title":"Lancet"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/apt.13069\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T16:26:58Z","timestamp":1625416018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,14]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,3]]}},"URL":"https:\/\/doi.org\/10.1111\/apt.13069","relation":{},"ISSN":["0269-2813"],"issn-type":[{"value":"0269-2813","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,14]]}}}