{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:39:35Z","timestamp":1788503975699,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The features of proton pump inhibitor\u2010responsive oesophageal eosinophilia (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>) are similar to those of eosinophilic oesophagitis (EoE), but <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> demonstrates symptomatic and histological responses to <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy. Several studies have shown that basophils play a crucial role in the pathogenesis of allergic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify and compare basophil infiltration in the oesophageal epithelium in patients with EoE, <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>, gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>) and normal oesophagus (controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Biopsy specimens from 43 patients, including 12 with EoE, 11 with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>, 10 with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> and 10 normal oesophagus, were analysed. Immunohistochemistry was performed to quantify the number of basophils and mast cells in the oesophageal epithelium. Double immunofluorescence staining for thymic stromal lymphopoietin (<jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>) and basophils was performed. Patients with EoE were treated with swallowed fluticasone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences in clinical, endoscopic or histological features between patients with EoE and <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>. There were more basophils and mast cells in patients with EoE and <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> than in patients with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> and control subjects. Basophil infiltration of the oesophageal epithelium in patients with EoE was higher than that in patients with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> (3.6\u00a0\u00b1\u00a02.8 per high power field vs. 1.2\u00a0\u00b1\u00a00.9 per high power field respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02); however, there was no significant difference in mast cell infiltration between the two groups. <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> was highly expressed in the oesophageal epithelium in areas infiltrated by basophils. Steroid therapy significantly decreased intraepithelial basophils in patients with EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Basophils may play an important role in the pathogenesis of eosinophilic oesophagitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13141","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T06:20:59Z","timestamp":1424326859000},"page":"776-784","source":"Crossref","is-referenced-by-count":39,"title":["Basophil infiltration in eosinophilic oesophagitis and proton pump inhibitor\u2010responsive oesophageal eosinophilia"],"prefix":"10.1111","volume":"41","author":[{"given":"N.","family":"Iwakura","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tanigawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tohoku University Graduate School of Medicine Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tohoku University Graduate School of Medicine Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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