{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:01:33Z","timestamp":1791558093371,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008765","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Gastro-Ent\u00e9rologie","doi-asserted-by":"crossref","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100008765","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Functional gastrointestinal disorders\u2019 (FGID<\/jats:styled-content>s) associations with body mass index (BMI<\/jats:styled-content>) have not been thoroughly investigated in the general population.<\/jats:p><\/jats:sec>Aim<\/jats:title>To investigate the overlap between functional dyspepsia (FD<\/jats:styled-content>y), irritable bowel syndrome (IBS<\/jats:styled-content>), functional constipation (FC<\/jats:styled-content>) and functional diarrhoea (FD<\/jats:styled-content>h) and the relationship between BMI<\/jats:styled-content> and those diagnoses in a large French adult population.<\/jats:p><\/jats:sec>Methods<\/jats:title>Subjects participating in the Nutrinet\u2010Sant\u00e9 cohort study completed a questionnaire based on Rome III<\/jats:styled-content> criteria. Anthropometrics, socio\u2010demographical and lifestyle data were collected via self\u2010administered questionnaires. Associations between BMI<\/jats:styled-content> and FGID<\/jats:styled-content>s were investigated with multivariate logistic regression.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 35\u00a0447 subjects were included in the analysis. Among subjects with FGIDs, 10.4% presented more than one disorder. [FD<\/jats:styled-content>y coexisted with IBS<\/jats:styled-content> (23.6%) and FC<\/jats:styled-content> (15.1%)].<\/jats:p>Associations between BMI<\/jats:styled-content> and FD<\/jats:styled-content>y differed according to sex. In females, higher odds were observed for underweight and obesity subgroups (OR<\/jats:styled-content>\u00a0=\u00a01.26 (95% CI: 0.99\u20131.59), OR<\/jats:styled-content>\u00a0=\u00a01.35 (1.08\u20131.69), OR<\/jats:styled-content>\u00a0=\u00a01.20 (0.81\u20131.77), OR<\/jats:styled-content>\u00a0=\u00a01.47 (0.89\u20132.42) for underweight, class I, II<\/jats:styled-content> and III<\/jats:styled-content> obesity respectively compared with normal BMI<\/jats:styled-content>), forming a U\u2010shaped relationship confirmed with nonlinear model (P<\/jats:italic>\u00a0<\u00a00.001). In females, FD<\/jats:styled-content>h was associated with BMI<\/jats:styled-content> [OR<\/jats:styled-content>\u00a0=\u00a01.05 (1.03\u20131.07), P<\/jats:italic>\u00a0<\u00a00.001]. In males, a negative association between BMI<\/jats:styled-content> and IBS<\/jats:styled-content> was observed [OR<\/jats:styled-content>\u00a0=\u00a00.97 (0.94\u20130.99), P<\/jats:italic>=0.04]. Other associations were not significant.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study showed an important overlap in FGID<\/jats:styled-content>s, supporting the contention of common pathophysiological mechanisms. Relationships between BMI<\/jats:styled-content> and FGID<\/jats:styled-content>s appeared to be sex\u2010dependent. Interaction by sex in the association between BMI<\/jats:styled-content> and FGID<\/jats:styled-content>s should therefore be further explored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13143","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:21:17Z","timestamp":1425255677000},"page":"758-767","source":"Crossref","is-referenced-by-count":112,"title":["Functional gastrointestinal disorders in 35\u00a0447 adults and their association with body mass index"],"prefix":"10.1111","volume":"41","author":[{"given":"D.","family":"Le Pluart","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris 13 Sorbonne Paris Cit\u00e9 Equipe de Recherche en Epid\u00e9miologie Nutritionnelle (EREN) Centre de Recherche en Epid\u00e9miologie et Biostatistiques (CRESS) UMR 1153 Inserm U1125 Inra Cnam COMUE Sorbonne Paris Cit\u00e9 Bobigny 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