{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:32:01Z","timestamp":1764102721116},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>While the Rome III<\/jats:styled-content> classification recognises functional constipation (FC<\/jats:styled-content>) and constipation predominant IBS (IBS\u2010C) as distinct disorders, recent evidence has suggested that these disorders are difficult to separate in clinical practice.<\/jats:p><\/jats:sec>Aim<\/jats:title>To identify whether clinical and lifestyle factors differentiate Rome III<\/jats:styled-content>\u2010defined IBS<\/jats:styled-content>\u2010C from FC<\/jats:styled-content> based on gastrointestinal symptoms and lifestyle characteristics.<\/jats:p><\/jats:sec>Method<\/jats:title>3260 people randomly selected from the Australian population returned a postal survey. FC<\/jats:styled-content> and IBS<\/jats:styled-content>\u2010C were defined according to Rome III<\/jats:styled-content>. The first model used logistic regression to differentiate IBS<\/jats:styled-content>\u2010C from FC<\/jats:styled-content> based on lifestyle, quality\u2010of\u2010life and psychological characteristics. The second approach was data\u2010driven employing latent class analysis (LCA<\/jats:styled-content>) to identify naturally occurring clusters in the data considering all symptoms involved in the Rome III<\/jats:styled-content> criteria for IBS<\/jats:styled-content>\u2010C and FC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>We found n<\/jats:italic>\u00a0=\u00a0206 (6.5%; 95% CI<\/jats:styled-content> 5.7\u20137.4%) people met strict Rome III FC<\/jats:styled-content> whereas n<\/jats:italic>\u00a0=\u00a0109 (3.5%; 95% CI<\/jats:styled-content> 2.8\u20134.1%) met strict Rome III IBS<\/jats:styled-content>\u2010C. The case\u2013control approach indicated that FC<\/jats:styled-content> patients reported an older age at onset of constipation, were less likely to exercise, had higher mental QoL and less health care seeking than IBS<\/jats:styled-content>\u2010C. LCA<\/jats:styled-content> yielded one latent class that was predominantly (75%) FC<\/jats:styled-content>, while the other class was approximately half IBS<\/jats:styled-content>\u2010C and half FC<\/jats:styled-content>. The FC<\/jats:styled-content>\u2010dominated latent class had clearly lower levels of symptoms used to classify IBS<\/jats:styled-content> (pain\u2010related symptoms) and was more likely to be male (P<\/jats:italic>\u00a0=\u00a00.046) but was otherwise similar in distribution of lifestyle factors to the mixed class.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The latent class analysis approach suggests a differentiation based more on symptom severity rather than the Rome III<\/jats:styled-content> view.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13149","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T09:25:54Z","timestamp":1425461154000},"page":"856-866","source":"Crossref","is-referenced-by-count":51,"title":["Differentiation of functional constipation and constipation predominant irritable bowel syndrome based on Rome III<\/scp> criteria: a population\u2010based study"],"prefix":"10.1111","volume":"41","author":[{"given":"N. A.","family":"Koloski","sequence":"first","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychology Macquarie University North Ryde NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Young","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Talley","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/13.2.156"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04114.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05783.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05259.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01303162"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01642.x"},{"key":"e_1_2_7_9_1","first-page":"307","article-title":"Guidelines\u2010Rome III diagnostic criteria for functional gastrointestinal disorders","volume":"15","author":"Rome Foundation","year":"2006","journal-title":"J Gastrointest Liver Dis"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.07.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04809.x"},{"key":"e_1_2_7_12_1","first-page":"S3","article-title":"Definition, epidemiology and impact of chronic constipation (Review)","volume":"4","author":"Talley NJ","year":"2004","journal-title":"Rev Gastroenterological Dis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00974.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9298-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07465.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.480"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20392"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300474"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"S\u2010818","DOI":"10.1016\/S0016-5085(12)63182-5","article-title":"Subjects With Irritable Bowel Syndrome\u2010Constipation are more constipated than those with chronic constipation: Spectrum From a Population Based Study","volume":"142","author":"Mearin R","year":"2012","journal-title":"Gastroenterology"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.200"},{"key":"e_1_2_7_21_1","first-page":"835","volume-title":"Rome III: The Functional Gastrointestinal Disorders","author":"Whitehead WE","year":"2006"},{"key":"e_1_2_7_22_1","unstructured":"National Health Survey: Users\u2019 Guide \u2010 Electronic Publication 2007\u201308."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_7_24_1","volume-title":"SF\u201012: How to Score the SF\u201012 Physical and Health Summary Scales","author":"Ware JE","year":"1999"},{"key":"e_1_2_7_25_1","volume-title":"Mail and Telephone Surveys: The Total Design Method","author":"Dillman DA","year":"1978"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.127"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03238.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1639-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01735.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709002985"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02183.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03376.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)91500-X"},{"key":"e_1_2_7_34_1","first-page":"977","article-title":"Psychological evaluation of patients\u00a0with severe idiopathic constipation. Which instrument to use?","volume":"87","author":"Wald A","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_35_1","first-page":"A582","article-title":"Psychiatric assessment of patients with severe constipation","volume":"25","author":"Preston DM","year":"1984","journal-title":"Gut"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01663.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200523050-00006"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S35568"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90320-X"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-9-160"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:40:16Z","timestamp":1696495216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/apt.13149"],"URL":"https:\/\/doi.org\/10.1111\/apt.13149","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}