{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:59:10Z","timestamp":1792065550510,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Union\u2019s Seventh Framework Programme (FP7\/2007- 612 2013), project EarlyNutrition","award":["289346"],"award-info":[{"award-number":["289346"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>New evidence emerged on early feeding practices and the risk of coeliac disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To systematically update evidence on these practices to find out whether there is a need to revise current recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      and the Cochrane Library were searched from July 2012 (end of last search) to February 2015 for studies of any design that assessed the effect of gluten consumption and breastfeeding on the development of coeliac disease and\/or coeliac disease\u2010related autoimmunity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 21 publications, including two, new, large, randomised controlled trials performed in high\u2010risk infants. Exclusive or any breastfeeding, as well as breastfeeding at the time of gluten introduction, did not reduce the risk of developing coeliac disease during childhood. For infants at high risk of developing coeliac disease, gluten introduction at 4\u00a0months of age in very small amounts, or at 6 or 12\u00a0months of age, resulted in similar rates of coeliac disease diagnosis in early childhood. Later gluten introduction was associated with later development of coeliac specific autoimmunity and coeliac disease during childhood, but not total risk reduction. Observational studies indicate that consumption of a higher amount of gluten at weaning may increase the risk for coeliac disease development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Infant feeding practices (breastfeeding, time of gluten introduction) have no effect on the risk of developing coeliac disease during childhood (at least at specific timeframes evaluated in the included studies), necessitating an update of current European recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.13163","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T18:09:21Z","timestamp":1427479761000},"page":"1038-1054","source":"Crossref","is-referenced-by-count":108,"title":["Systematic review with meta\u2010analysis: early infant feeding and coeliac disease \u2013 update 2015"],"prefix":"10.1111","volume":"41","author":[{"given":"H.","family":"Szajewska","sequence":"first","affiliation":[{"name":"The Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Shamir","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chmielewska","sequence":"additional","affiliation":[{"name":"The Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pie\u015bcik\u2010Lech","sequence":"additional","affiliation":[{"name":"The Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Auricchio","sequence":"additional","affiliation":[{"name":"University Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ivarsson","sequence":"additional","affiliation":[{"name":"Epidemiology and Global Health Unit Department of Public Health and Clinical Medicine Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kolacek","sequence":"additional","affiliation":[{"name":"Referral Center for Paediatric Gastroenterology &amp; Nutrition Children's Hospital Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Koletzko","sequence":"additional","affiliation":[{"name":"University of Munich Medical Centre Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Korponay\u2010Szabo","sequence":"additional","affiliation":[{"name":"Heim P\u00e1l Children's Hospital Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Mearin","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ribes\u2010Koninckx","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology La Fe University Hospital Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Troncone","sequence":"additional","affiliation":[{"name":"University Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PREVENTCD Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306578"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.505931"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31818c52cc"},{"key":"e_1_2_8_6_1","unstructured":"EFSA Panel on Dietetic Products Nutrition and Allergies (NDA).Scientific opinion on the appropriate age for introduction of complementary feeding of infants. 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