{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:13:44Z","timestamp":1793830424654,"version":"4.6.1"},"reference-count":81,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dietary fibre supplements have been advocated for the management of chronic constipation (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) and irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). Recently, a fermentable oligosaccharide, disaccharide, monosaccharide and polyol (<jats:styled-content style=\"fixed-case\">FODMAP<\/jats:styled-content>) restricted diet has been recommended for<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To systematically examine recent evidence for dietary interventions with fibre in<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">FODMAP<\/jats:styled-content>\u2010restricted diet in<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, and provide recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched<jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">OVID<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">COCHRANE<\/jats:styled-content>databases from 2004 to 2014. Published studies in adults with<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>and constipation\u2010predominant<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C) that compared fibre with placebo\/alternative and<jats:styled-content style=\"fixed-case\">FODMAP<\/jats:styled-content>\u2010restricted diet with alternative were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 550 potentially eligible clinical trials on fibre, 11 studies were found and of 23 potentially eligible studies on<jats:styled-content style=\"fixed-case\">FODMAP<\/jats:styled-content>s, six were found. A meta\u2010analysis was not performed due to heterogeneity and methodological quality. Fibre was beneficial in 5\/7 studies in<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>and 3\/3 studies in<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C.<jats:styled-content style=\"fixed-case\">FODMAP<\/jats:styled-content>\u2010restricted diet improved overall<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>symptoms in 4\/4 and<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C symptoms in 1\/3 studies and three studies did not meet inclusion criteria. There were significant disparities in subject selection, interventions and outcome assessments in both fibre and<jats:styled-content style=\"fixed-case\">FODMAP<\/jats:styled-content>s studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fibre supplementation is beneficial in mild to moderate<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C, although larger, more rigorous and long\u2010term<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s are needed (Fair evidence\u2013Level<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, Grade B). Although the<jats:styled-content style=\"fixed-case\">FODMAP<\/jats:styled-content>\u2010restricted diet may be effective in short\u2010term management of selected patients with<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>(Fair evidence\u2013Level<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, Grade C) and<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C (Poor evidence\u2013Level<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, Grade C), more rigorous trials are needed to establish long\u2010term efficacy and safety, particularly on colonic health and microbiome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13167","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T01:53:00Z","timestamp":1429753980000},"page":"1256-1270","source":"Crossref","is-referenced-by-count":260,"title":["Systematic review: dietary fibre and<scp>FODMAP<\/scp>\u2010restricted diet in the management of constipation and irritable bowel syndrome"],"prefix":"10.1111","volume":"41","author":[{"given":"S. S. C.","family":"Rao","sequence":"first","affiliation":[{"name":"Section\u00a0of Gastroenterology\/Hepatology Department of Internal Medicine Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yu","sequence":"additional","affiliation":[{"name":"Section\u00a0of Gastroenterology\/Hepatology Department of Internal Medicine Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fedewa","sequence":"additional","affiliation":[{"name":"Food and Nutrition Department Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.028"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70169-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04114.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0249-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckp098"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32832bfdf0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-11-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05259.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04169.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2010000700018"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1020-49892006000700003"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/532734"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9087-3"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.6388"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0000000000000074"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9509-2"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.4.389"},{"key":"e_1_2_12_21_1","first-page":"5","article-title":"Pattern of irritable bowel syndrome and its impact on quality of life in primary health care center attendees, Suez governorate, Egypt","volume":"9","author":"Abdulmajeed A","year":"2011","journal-title":"Pan Afr Med J"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/1596-3519.57241","article-title":"Prevalence of irritable bowel syndrome: a community survey in an African population","volume":"8","author":"Okeke EN","year":"2009","journal-title":"Ann Afr Med"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.775328"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05913.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04273.x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200523050-00006"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.10.010"},{"issue":"1","key":"e_1_2_12_29_1","first-page":"S7","article-title":"Total costs of IBS: employer and managed care perspective","volume":"11","author":"Cash B","year":"2005","journal-title":"The American journal of managed care"},{"issue":"1","key":"e_1_2_12_30_1","first-page":"S1","article-title":"An evidence\u2010based position statement on the management of irritable bowel syndrome","volume":"104","author":"Brandt LJ","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_12_31_1","volume-title":"Brocklehurst's Textbook of Geriatric Medicine and Gerontology","author":"Harari D","year":"2010"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198910000-00008"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000167"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.015"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.423"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554713"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12938"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.49"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2011.01162.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40925.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.63"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.187"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04602.x"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(01)00261-6"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602317"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602670"},{"key":"e_1_2_12_47_1","first-page":"12","article-title":"The effect of a fibre enriched dietary milk product in chronic primary idiopatic constipation","volume":"23","author":"Lopez Roman J","year":"2008","journal-title":"Nutr Hosp"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-010-0053-6"},{"key":"e_1_2_12_49_1","first-page":"123","article-title":"Microbiota benefits after inulin and partially hydrolized guar gum supplementation: a randomized clinical trial in constipated women","volume":"27","author":"Linetzky Waitzberg D","year":"2012","journal-title":"Nutr Hosp"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-011-0722-4"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04594.x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/146642400512500112"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2011.5.1.22"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i33.4563"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2012.01263.x"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06370.x"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12128"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.051"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.046"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i43.16215"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.062"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-014-0379-z"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302167"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0370-0"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1991.tb02739.x"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19880119"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/284283a0"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2008.08.007"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.81.2.380"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1995.tb07203.x"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00433.x"},{"key":"e_1_2_12_72_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1742-1241.1986.tb07949.x","article-title":"A general practice study of the efficacy of Regulan in functional constipation","volume":"40","author":"Fenn GC","year":"1986","journal-title":"Br J Clin Pract"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12123"},{"key":"e_1_2_12_74_1","unstructured":"ErdoganA AdameEC ValestinJ O'BanionM ThiruvaiyaruD RaoSSC.Suprafiber versus psyllium in chronic constipation: a randomized controlled trial\u2010interim analysis. 1st Federation of Neurogastroenterology and Motility Meeting (Abstract) 2014."},{"key":"e_1_2_12_75_1","first-page":"425","article-title":"Diagnosis and treatment of irritable bowel syndrome","volume":"11","author":"Suares NC","year":"2011","journal-title":"Discov Med"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.195"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2011.09.025"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-009-0056-9"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.105"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307264"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602367"},{"issue":"1","key":"e_1_2_12_82_1","first-page":"S","article-title":"Effects of low\u2010fodmap and gluten\u2010free diets in irritable bowel syndrome patients. a double\u2010blind randomized controlled clinical study","author":"Piacentino D","year":"2014","journal-title":"Gastroenterology"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13167","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T15:25:51Z","timestamp":1717860351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,22]]},"references-count":81,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/apt.13167"],"URL":"https:\/\/doi.org\/10.1111\/apt.13167","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,22]]}}}