{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:16:06Z","timestamp":1793128566689,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eosinophilic oesophagitis (EoE) is primarily diagnosed by clinicians. There are less than a handful of epidemiological studies in EoE that have included elderly patients (&gt;65\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the prevalence of elderly subjects among EoE patients and compare their clinical presentation, associated conditions and treatment modalities with adult and paediatric EoE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A large nationwide database (Explorys) between January 2011 and January 2014 was used. The term \u2018Eosinophilic Oesophagitis\u2019 was used in the Explorys search tool. The patient population was divided into three groups, Paediatric (&lt;18\u00a0years), Adult (18\u201365\u00a0years) and Elderly (&gt;65\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 4840 patients coded as EoE. The total estimated prevalence was 50.6 cases per 100\u00a0000 patients (0.05%). A total of 360 cases (7.44%) were elderly patients with an estimated prevalence rate of 18.6 cases per 100\u00a0000. Across all age groups, the majority of EoE patients were Caucasians and males. A significantly greater proportion of older patients had concomitant <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>. Dysphagia was the most common symptom among elderly EoE patients as compared with the paediatric EoE patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The proportion of elderly EoE patients with food allergies or asthma was significantly lower as compared with paediatric and adult EoE patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Oesophageal dilation and\/or proton pump inhibitor treatment were the most commonly used therapeutic modalities in elderly EoE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Eosinophilic oesophagitis is uncommon in elderly subjects and the clinical presentation is markedly different as compared with adults or the paediatric population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13171","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T22:14:19Z","timestamp":1427235259000},"page":"1016-1022","source":"Crossref","is-referenced-by-count":56,"title":["The 2011\u20132014 prevalence of eosinophilic oesophagitis in the elderly amongst 10 million patients in the United States"],"prefix":"10.1111","volume":"41","author":[{"given":"C.","family":"Maradey\u2010Romero","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology The Esophageal and Swallowing Center Case Western Reserve University MetroHealth Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Prakash","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology The Esophageal and Swallowing Center Case Western Reserve University MetroHealth Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Center for Health Care Research and Policy Case Western Reserve University at MetroHealth Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Perzynski","sequence":"additional","affiliation":[{"name":"Center for Health Care Research and Policy Case Western Reserve University at MetroHealth Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Fass","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology The Esophageal and Swallowing Center Case Western Reserve University MetroHealth Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.71"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(77)80034-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90710-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296781"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90637-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200408263510924"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01352.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04411.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225590.08825.77"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.10.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0706-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01512.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03795.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12009"},{"key":"e_1_2_7_18_1","unstructured":"International health terminology standards development organisation. 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