{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:53:56Z","timestamp":1775073236050,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,4,19]],"date-time":"2015-04-19T00:00:00Z","timestamp":1429401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>) is historically classified into type 1 and type 2 on the basis of the autoantibody profile, anti\u2010nuclear and\/or anti\u2010smooth muscle antibodies being the serological markers of type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>, whereas anti\u2010liver\/kidney microsomal antibody type 1 and\/or anti\u2010liver cytosol antibody type 1 characterise type 2 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate whether such a distinction is justified on the basis of different expression of the disease in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six adult patients with type 2 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> and 52 age\u2010 and sex\u2010matched patients with type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>, representative of the entire cohort of adults with type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>, were compared at onset and during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At diagnosis, median age was 26\u00a0years (range 17\u201353), female sex 86%, acute presentation 43%, severe liver histology 54%, cirrhosis 14%, complete response to treatment 52%, progression of the disease 17%, and median disease duration 72\u00a0months (range 12\u2013280). <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*0301 was present in 26%, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*0401 in 23% and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*0701 in 25%. Clinical presentation, biochemical parameters, severe liver histology, genetic profile, response rate and progression of the disease were identical between type 1 and type 2 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is not enough clinical, biochemical, histological or genetic reason to subdivide adults with autoimmune hepatitis into type 1 and type 2 on the basis of the autoantibody profile, and the term \u2018autoimmune hepatitis\u2019 without qualification should be preferred.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13210","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T03:04:53Z","timestamp":1429499093000},"page":"1281-1287","source":"Crossref","is-referenced-by-count":41,"title":["Type 1 and type 2 autoimmune hepatitis in adults share the same clinical 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