{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:54:20Z","timestamp":1793426060502,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Irritable bowel syndrome is a widespread disorder with a marked socioeconomic burden. Previous studies support the proposal that a subset of patients with features compatible with diarrhoea\u2010predominant\n IBS<\/jats:styled-content>\n (\n IBS<\/jats:styled-content>\n \u2010D) have bile acid malabsorption (\n BAM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To perform a systematic review and meta\u2010analysis to assess the prevalence of\n BAM<\/jats:styled-content>\n in patients meeting the accepted criteria for\n IBS<\/jats:styled-content>\n \u2010D.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n MEDLINE<\/jats:styled-content>\n and\n EMBASE<\/jats:styled-content>\n were searched up to March 2015. Studies recruiting adults with\n IBS<\/jats:styled-content>\n \u2010D, defined by the Manning, Kruis, Rome I,\n II<\/jats:styled-content>\n or\n III<\/jats:styled-content>\n criteria and which used 23\u2010seleno\u201025\u2010homotaurocholic acid (Se\n HCAT<\/jats:styled-content>\n ) testing for the assessment of\n BAM<\/jats:styled-content>\n were included.\n BAM<\/jats:styled-content>\n was defined as 7\u00a0day Se\n HCAT<\/jats:styled-content>\n retention of <10%. We calculated the rate of\n BAM<\/jats:styled-content>\n and 95% confidence intervals (\n CI<\/jats:styled-content>\n ) using a random effects model. The methodological quality of included studies was evaluated using the Quality Assessment for Diagnostic Accuracy Studies (\n QUADAS<\/jats:styled-content>\n \u20102).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The search strategy identified six relevant studies comprising 908 individuals. The rate of\n BAM<\/jats:styled-content>\n ranged from 16.9% to 35.3%. The pooled rate was 28.1% (95%\n CI<\/jats:styled-content>\n : 22.6\u201334%). There was significant heterogeneity in effect sizes (\n Q<\/jats:italic>\n \u2010test \u03c7\n 2<\/jats:sup>\n \u00a0=\u00a017.9,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.004;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a072.1%). The type of diagnostic criteria used or study country did not significantly modify the effect.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These data provide evidence that in excess of one quarter of patients meeting accepted criteria for\n IBS<\/jats:styled-content>\n \u2010D have bile acid malabsorption. This distinction has implications for the interpretation of previous studies, as well as contemporaneous clinical practice and future guideline development.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.13227","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T04:51:30Z","timestamp":1430110290000},"page":"3-11","source":"Crossref","is-referenced-by-count":194,"title":["Systematic review with meta\u2010analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea"],"prefix":"10.1111","volume":"42","author":[{"given":"S. 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C.","family":"Ford","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital Leeds UK"},{"name":"Leeds Institute of Biomedical and Clinical Sciences Leeds University Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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