{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:55:04Z","timestamp":1791950104785,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Project of Chinese Ministry of Science and Technology","award":["2012ZX10002007, 2013ZX10002001"],"award-info":[{"award-number":["2012ZX10002007, 2013ZX10002001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["1171579, 81201287, 81371832"],"award-info":[{"award-number":["1171579, 81201287, 81371832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Glutathione\u2010S\u2010transferase P1 (GSTP<\/jats:styled-content>1<\/jats:italic>) methylation has been demonstrated to be associated with oxidative stress induced liver damage in acute\u2010on\u2010chronic hepatitis B liver failure (ACHBLF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Aim<\/jats:title>To evaluate the methylation level of GSTP<\/jats:styled-content>1<\/jats:italic> promoter in acute\u2010on\u2010chronic hepatitis B liver failure and determine its predictive value for prognosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred and five patients with acute\u2010on\u2010chronic hepatitis B liver failure, 86 with chronic hepatitis B (CHB<\/jats:styled-content>) and 30 healthy controls (HC<\/jats:styled-content>) were retrospectively enrolled. GSTP<\/jats:styled-content>1<\/jats:italic> methylation level in peripheral mononuclear cells (PBMC<\/jats:styled-content>) was detected by MethyLight. Clinical and laboratory parameters were obtained.<\/jats:p><\/jats:sec>Results<\/jats:title>GSTP<\/jats:styled-content>1<\/jats:italic> methylation levels were significantly higher in patients with acute\u2010on\u2010chronic hepatitis B liver failure (median 16.84%, interquartile range 1.83\u201359.05%) than those with CHB<\/jats:styled-content> (median 1.25%, interquartile range 0.48\u20132.47%; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01) and HC<\/jats:styled-content> (median 0.80%, interquartile range 0.67\u20131.27%; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01). In acute\u2010on\u2010chronic hepatitis B liver failure group, nonsurvivors showed significantly higher GSTP<\/jats:styled-content>1<\/jats:italic> methylation levels (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05) than survivors. GSTP<\/jats:styled-content>1<\/jats:italic> methylation level was significantly correlated with total bilirubin (r<\/jats:italic>\u00a0=\u00a00.29, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01), prothrombin time activity (r<\/jats:italic>\u00a0=\u00a0\u22120.24, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.01) and model for end\u2010stage liver disease (MELD<\/jats:styled-content>) score (r<\/jats:italic>\u00a0=\u00a00.26, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.01). When used to predict 1\u2010 or 2\u2010month mortality of acute\u2010on\u2010chronic hepatitis B liver failure, GSTP<\/jats:styled-content>1<\/jats:italic> methylation showed significantly better predictive value than MELD<\/jats:styled-content> score [area under the receiver operating characteristic curve (AUC<\/jats:styled-content>) 0.89 vs. 0.72, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01; AUC<\/jats:styled-content> 0.83 vs. 0.70, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05 respectively]. Meanwhile, patients with GSTP<\/jats:styled-content>1<\/jats:italic> methylation levels above the cut\u2010off points showed significantly poorer survival than those below (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Aberrant GSTP<\/jats:styled-content>1<\/jats:italic> promoter methylation exists in acute\u2010on\u2010chronic hepatitis B liver failure and shows high predictive value for short\u2010term mortality. It might serve as a potential prognostic marker for acute\u2010on\u2010chronic hepatitis B liver failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13271","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T14:07:19Z","timestamp":1433426839000},"page":"319-329","source":"Crossref","is-referenced-by-count":38,"title":["Aberrant GSTP<\/scp>1<\/i> promoter methylation predicts short\u2010term prognosis in acute\u2010on\u2010chronic hepatitis B liver failure"],"prefix":"10.1111","volume":"42","author":[{"given":"S.","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u2010K.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan 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