{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:10:31Z","timestamp":1792919431317,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T00:00:00Z","timestamp":1433808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK090073"],"award-info":[{"award-number":["K23DK090073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Seasonal variation has been reported in diagnosis of eosinophilic oesophagitis (EoE), but results are not consistent across studies and there are no national\u2010level data in the USA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine if there is seasonal variation in diagnosis of oesophageal eosinophilia and EoE in the USA, while accounting for factors such as climate zone and geographic variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study using a USA national pathology database. Patients with oesophageal eosinophilia (\u226515 eosinophils per high\u2010power field) comprised the primary case definition and were compared to those with normal oesophageal biopsies. We calculated the crude and adjusted odds of oesophageal eosinophilia by season, as well as by day of the year. Sensitivity analyses were performed using more restrictive case definitions of EoE, and after stratification by climate zone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exactly, 14\u00a0524 cases with oesophageal eosinophilia and 90\u00a0459 normal controls were analysed. The adjusted odds of oesophageal eosinophilia were higher in the late spring and summer months, with the highest odds in July (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 1.13; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.03\u20131.24). These findings persisted with increasing levels of oesophageal eosinophilia, as well as across EoE case definitions. Seasonal variation was strongest in temperate and cold climates, and peak diagnosis varied by climate zone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a mild but consistent seasonal variation in the diagnosis of oesophageal eosinophilia and EoE, with cases more frequently diagnosed during summer months. These findings take into account climate and geographic differences, suggesting that aeroallergens may contribute to disease development or flare.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13273","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T02:06:18Z","timestamp":1433988378000},"page":"461-469","source":"Crossref","is-referenced-by-count":64,"title":["Seasonal variation in detection of oesophageal eosinophilia and eosinophilic oesophagitis"],"prefix":"10.1111","volume":"42","author":[{"given":"E. T.","family":"Jensen","sequence":"first","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing Division of Gastroenterology and Hepatology Department of Medicine University of North Carolina School of Medicine Chapel Hill NC USA"},{"name":"Center for Gastrointestinal Biology and Disease Division of Gastroenterology and Hepatology Department of Medicine University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. D.","family":"Shah","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing Division of Gastroenterology and Hepatology Department of Medicine University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina Chapel Hill NC USA"},{"name":"Nicholas School of the Environment Duke University Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sonnenberg","sequence":"additional","affiliation":[{"name":"Portland VA Medical Center and Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Genta","sequence":"additional","affiliation":[{"name":"Miraca Life Sciences Research Institute Irving TX USA"},{"name":"Dallas Veterans Affairs Medical Center University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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