{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:37:40Z","timestamp":1767825460238,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bacterial resistance of <jats:italic>Helicobacter pylori<\/jats:italic> to antibiotics is increasing and it often leads to failure of antibiotic treatment. A new sitafloxacin\u2010based triple therapy was developed to counter this situation; the fluoroquinolone sitafloxacin has a low minimum inhibitory concentration for <jats:italic>H. pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the efficacy in Japanese patients of sitafloxacin\u2010based triple therapy and document its efficacy in relation to anti\u2010microbial susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the efficacy of a 1\u2010week sitafloxicin\u2010based regimen of rabeprazole 10\u00a0mg four times daily (q.d.s.), metronidazole 250\u00a0mg twice daily (b.d.) and sitafloxacin 100\u00a0mg b.d. in 180 <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive Japanese patients (first\u2010line treatment: <jats:italic>n<\/jats:italic>\u00a0=\u00a045, second\u2010line; <jats:italic>n<\/jats:italic>\u00a0=\u00a041, third\u2010line: <jats:italic>n<\/jats:italic>\u00a0=\u00a094). At 8\u00a0weeks, patients were given the <jats:sup>13<\/jats:sup>C\u2010urea breath test to assess eradication status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eradication rate was 92.2% [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 87.3\u201395.7%, 166\/180] in intention\u2010to\u2010treat analysis. Although the eradication rate was higher in patients treated with first\u2010line therapy [45\/45 (100%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 83.4\u2013100%)] than in those with second\u2010 [38\/41 (92.7%, 80.1\u201398.5%)] or third\u2010line therapy [83\/94 (88.3%, 80.0\u201394.0%)], no significant differences were noted with respect to the number of previous therapy attempts (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.054). Eradication rates in patients infected with sensitive\u2010 and resistant strains to metronidazole were 96.6% (28\/29) and 96.3% (77\/80) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.941), respectively, while rates were 98.4% (60\/61) in sitafloxacin\u2010sensitive and 50.0% (1\/2) in sitafloxacin resistant strains (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sitofloxacin\u2010based triple therapy with metronidazole b.d. and rabeprazole q.d.s. achieved an eradication rate exceeding 88%, irrespective of eradication history, <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C19 genotype, or metronidazole resistance status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13280","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T10:47:13Z","timestamp":1434365233000},"page":"477-483","source":"Crossref","is-referenced-by-count":35,"title":["High 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