{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:38:54Z","timestamp":1791225534130,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance entero\u2010colonography enables accurate assessment of ileocolonic Crohn's disease, but the need for bowel cleansing and rectal enema limits considerably its use in daily practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We evaluated the accuracy of diffusion\u2010weighted magnetic resonance entero\u2010colonography with neither bowel cleansing nor rectal enema to assess endoscopic activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four Crohn's disease patients underwent prospectively and consecutively diffusion\u2010weighted magnetic resonance entero\u2010colonography [with apparent diffusion coefficient (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>) and Clermont score calculation] and ileocolonoscopy [with Crohn's Disease Endoscopic Index of Severity (<jats:styled-content style=\"fixed-case\">CDEIS<\/jats:styled-content>) and Simplified Endoscopic score for Crohn's Disease (<jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) calculation].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> was inversely correlated with total <jats:styled-content style=\"fixed-case\">CDEIS<\/jats:styled-content> (\u03c1\u00a0=\u00a0\u22120.40; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0067) and total <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (\u03c1\u00a0=\u00a0\u22120.33; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032). Considering the 194 segments, <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> was inversely correlated with segmental <jats:styled-content style=\"fixed-case\">CDEIS<\/jats:styled-content> (\u22120.48; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and segmental <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (\u22120.44; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values were lower in segments with deep ulcers (1.30\u00a0\u00b1\u00a00.23) or superficial ulcerations (1.75\u00a0\u00b1\u00a00.64) than in non\u2010ulcerated segments (2.15\u00a0\u00b1\u00a00.5) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Using a receiver operating curve, we determined that segmental <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> &lt;1.42 detected endoscopic deep ulcerations with sensitivity\u00a0=\u00a00.91 and specificity\u00a0=\u00a00.83 (Area under the curve\u00a0=\u00a00.84; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Segmental <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> &lt;1.88 detected endoscopic superficial ulcerations with sensitivity\u00a0=\u00a00.64 and specificity\u00a0=\u00a00.75. The segmental <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values decreased when the ulcerations size increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). Clermont score correlated with ileal <jats:styled-content style=\"fixed-case\">CDEIS<\/jats:styled-content> (0.63; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and ileal <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (0.58; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Clermont score was higher in ulcerated segments (23.3\u00a0\u00b1\u00a08.4) than in non\u2010ulcerated segments (12.4\u00a0\u00b1\u00a010.0) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and increased with ulcers size (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). Clermont score &gt;18.9 detected ulcerations with sensitivity\u00a0=\u00a00.79 and specificity\u00a0=\u00a00.73.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diffusion\u2010weighted magnetic resonance entero\u2010colonography using apparent diffusion coefficient and Clermont score was effective to indirectly detect endoscopic ulcerations in ileocolonic Crohn's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13287","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T07:53:41Z","timestamp":1434614021000},"page":"452-460","source":"Crossref","is-referenced-by-count":52,"title":["Diffusion\u2010weighted magnetic resonance imaging is effective to detect ileocolonic ulcerations in Crohn's disease"],"prefix":"10.1111","volume":"42","author":[{"given":"A.","family":"Buisson","sequence":"first","affiliation":[{"name":"Gastroenterology department University Hospital Estaing Clermont\u2010Ferrand France"},{"name":"Microbes, Intestine, Inflammation and Susceptibility of the Host UMR 1071 Inserm\/Universit\u00e9 d'Auvergne; 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