{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:28:20Z","timestamp":1770136100834,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polycystic liver disease is associated with impaired health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>). Somatostatin analogues reduce hepatomegaly in polycystic liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine whether somatostatin analogues improve <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> and to identify factors associated with change in <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> in polycystic liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We pooled data from two randomized, double\u2010blind, placebo\u2010controlled trials that evaluated <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> using the Short\u2010Form 36 (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036) in 96 polycystic liver disease patients treated 6\u201012\u00a0months with somatostatin analogues or placebo. The <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 contains a summarizing physical and mental component score and was administered at baseline and at the end of treatment. We used random effect models to delineate the effect of somatostatin analogues on <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>. We determined the effect of demographics, height\u2010adjusted liver volume, change in liver volume, somatostatin analogue\u2010associated side effects with change in <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>. In patients with autosomal dominant polycystic kidney disease, we estimated the effect of height\u2010adjusted kidney volume and change in kidney volume in relation to <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Physical component scores improved with somatostatin analogues, but remained unchanged with placebo (3.41\u00a0\u00b1\u00a01.29 vs. \u22120.71\u00a0\u00b1\u00a01.54, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044). Treatment had no impact on the mental component score. Large liver volume was independently associated with larger <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> decline during follow up (\u22124.04\u00a0\u00b1\u00a02.02 points per logarithm liver volume, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049). In autosomal dominant polycystic kidney disease, patients with large liver and kidney volumes had larger decline in <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> (5.36\u00a0\u00b1\u00a02.54 points per logarithm liver volume; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.040 and \u22124.00\u00a0\u00b1\u00a01.88 per logarithm kidney volume; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Somatostatin analogues improve <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> in symptomatic polycystic liver disease. Halting the progressive nature of polycystic liver disease is necessary to prevent further decline of <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> in severe hepatomegaly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13301","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T08:20:21Z","timestamp":1435738821000},"page":"591-598","source":"Crossref","is-referenced-by-count":36,"title":["Somatostatin analogues improve health\u2010related quality of life in polycystic liver disease: a pooled analysis of two randomised, placebo\u2010controlled trials"],"prefix":"10.1111","volume":"42","author":[{"given":"M. K.","family":"Neijenhuis","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J. G.","family":"Gevers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Nevens","sequence":"additional","affiliation":[{"name":"Department of Hepatology University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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