{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:23:25Z","timestamp":1784647405072,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["33CS30_148422"],"award-info":[{"award-number":["33CS30_148422"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies that systematically assess change in ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) extent over time in adult patients are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess changes in disease extent over time and to evaluate clinical parameters associated with this change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Swiss <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> cohort study were analysed. We used logistic regression modelling to identify factors associated with a change in disease extent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 918 <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> patients (45.3% females) were included. At diagnosis, <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> patients presented with the following disease extent: proctitis [199 patients (21.7%)], left\u2010sided colitis [338 patients (36.8%)] and extensive colitis\/pancolitis [381 (41.5%)]. During a median disease duration of 9 [4\u201316] years, progression and regression was documented in 145 patients (15.8%) and 149 patients (16.2%) respectively. In addition, 624 patients (68.0%) had a stable disease extent. The following factors were identified to be associated with disease progression: treatment with systemic glucocorticoids [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 1.704, <jats:italic>P<\/jats:italic> = 0.025] and calcineurin inhibitors (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.716, <jats:italic>P<\/jats:italic> = 0.005). No specific factors were found to be associated with disease regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Over a median disease duration of 9 [4\u201316] years, about two\u2010thirds of <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> patients maintained the initial disease extent; the remaining one\u2010third had experienced either progression or regression of the disease extent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13307","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T05:47:10Z","timestamp":1436161630000},"page":"540-548","source":"Crossref","is-referenced-by-count":24,"title":["Systematic analysis of factors associated with progression and regression of ulcerative colitis in 918 patients"],"prefix":"10.1111","volume":"42","author":[{"given":"E.","family":"Safroneeva","sequence":"first","affiliation":[{"name":"University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vavricka","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"},{"name":"Stadtspital Triemli Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fournier","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Vaudois et Universit\u00e9 de Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Seibold","sequence":"additional","affiliation":[{"name":"Tiefenauspital Bern Bern Switzerland"},{"name":"Inselspital\/University Hospital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mottet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Vaudois et Universit\u00e9 de Lausanne Lausanne Switzerland"},{"name":"H\u00f4pital de Neuch\u00e2tel Neuch\u00e2tel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nydegger","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Vaudois et Universit\u00e9 de Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ezri","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Vaudois et Universit\u00e9 de Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Straumann","sequence":"additional","affiliation":[{"name":"University Hospital of Basel Basel Switzerland"},{"name":"Praxis R\u00f6merhof Olten Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rogler","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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