{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:40:14Z","timestamp":1773326414566,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Portal hypertension is the strongest predictor of virological response to pegylated interferon (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>)\/ribavirin in patients with chronic hepatitis C (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>)\u2010related cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effects of portal pressure assessed by hepatic venous pressure gradient (<jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>) measurement on virological responses in patients treated with <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010free regimens outside of clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six patients with <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> and cirrhosis who underwent <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> measurement before starting an <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010free therapy were retrospectively studied. Patients were treated with sofosbuvir in combination with daclatasvir (<jats:italic>n<\/jats:italic>\u00a0=\u00a032), ribavirin (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) or simeprevir (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), or the combination of simeprevir\/daclatasvir (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), for 12\u201324\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hepatic venous pressure gradient values \u226510\u00a0mmHg and \u226516\u00a0mmHg were observed in 41 (73%) and 31 (55%) patients respectively. The distributions of treatment regimens and durations were comparable between patients with or without portal hypertension. Patients with portal hypertension had lower platelet counts and albumin levels, while bilirubin levels, <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MELD<\/jats:styled-content> and Child\u2013Pugh scores were higher than in patients without portal hypertension. Importantly, rates of on\u2010treatment virological response and viral kinetics, as well as the rates of sustained virological response 12\u00a0weeks after the end of therapy [96% (54\/56)] were not affected by portal hypertension. Anti\u2010viral therapy improved liver stiffness, platelet count, serum albumin and bilirubin levels, as well as prothrombin time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to demonstrate that <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010free regimens overcome the negative effect of portal hypertension on virological responses and viral kinetics. Improvements in liver stiffness and platelet count might reflect an anti\u2010portal hypertensive effect of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010free treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13315","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T06:35:57Z","timestamp":1437028557000},"page":"707-718","source":"Crossref","is-referenced-by-count":46,"title":["Interferon\u2010free regimens for chronic hepatitis C overcome the effects of portal hypertension on virological responses"],"prefix":"10.1111","volume":"42","author":[{"given":"M.","family":"Mandorfer","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kozbial","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Freissmuth","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Schwabl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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