{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:56:56Z","timestamp":1793408216746,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The recognition of eosinophilic oesophagitis (EoE) has risen sharply, but its current epidemiology is still under debate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To estimate accurately the prevalence and incidence rates of EoE, by a systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">SCOPUS<\/jats:styled-content>\n                      databases were searched for population\u2010based studies on the epidemiology of EoE. Pooled incidence and prevalence rates, male:female and children:adult ratios, and geographical and temporal variations were calculated with random\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The search yielded 1334 references; the final quantitative summary included 13 population\u2010based studies from North America, Europe and Australia, with the results showing high heterogeneity. The pooled EoE incidence rate was 3.7\/100\u00a0000 persons\/year [95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ): 1.7\u20136.5] and was higher for adults (7; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1\u201318.3) than for children (5.1; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1.5\u201310.9).\n                    <\/jats:p>\n                    <jats:p>\n                      The pooled prevalence of EoE was 22.7 cases\/100\u00a0000 inhabitants (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 12.4\u201336), rising to 28.1 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 13\u201349) when studies with a lower risk of bias were considered; prevalence was higher in adults than in children (43.4; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 22.5\u201371.2 vs. 29.5; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 17.5\u201344.7, respectively), and in American compared to European studies.\n                    <\/jats:p>\n                    <jats:p>A steady rise in EoE incidence and prevalence rates was observed upon comparison of studies conducted before and after 2008. No significant publication bias was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Eosinophilic oesophagitis is an increasingly common diagnosis in North America and Europe. The population\u2010based incidence and prevalence of eosinophilic oesophagitis vary widely across individual studies, probably due to variations in diagnosis and risk of bias of research. More prospective, large\u2010scale, multicenter studies are needed to evaluate reported data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.13441","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T23:34:15Z","timestamp":1446075255000},"page":"3-15","source":"Crossref","is-referenced-by-count":268,"title":["Systematic review with meta\u2010analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population\u2010based studies"],"prefix":"10.1111","volume":"43","author":[{"given":"\u00c1.","family":"Arias","sequence":"first","affiliation":[{"name":"Research Unit Complejo Hospitalario La Mancha Centro Alc\u00e1zar de San Juan Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"P\u00e9rez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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