{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:53Z","timestamp":1772159993304,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Association for the Study of the Liver"},{"DOI":"10.13039\/501100003645","name":"National Cancer Center, Korea","doi-asserted-by":"crossref","award":["NCC-1410860"],"award-info":[{"award-number":["NCC-1410860"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n As a rare disease, only a few population\u2010based epidemiology studies of primary biliary cirrhosis (\n PBC<\/jats:styled-content>\n ) have been reported.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n To elucidate the nationwide prevalence, incidence, complications, fatality and direct medical costs of\n PBC<\/jats:styled-content>\n in South Korea.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The nationwide Health Insurance Review and Assessment Service claims data and Rare Intractable Disease registration data on\n PBC<\/jats:styled-content>\n , identified with the International Classification of Diseases (\n ICD<\/jats:styled-content>\n ) 10 code of K74.3, were obtained from 2009 to 2013. Age\u2010 and gender\u2010specific prevalence and incidence rates of\n PBC<\/jats:styled-content>\n were calculated, and data on complications, comorbidities, prescribed drugs, therapeutic procedures and direct medical costs were analysed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 2824 patients over 20 years old with\n PBC<\/jats:styled-content>\n were identified in 2009\u20132013 (female\u2010to\u2010male ratio 6.2, median age 57 years old). The average age\u2010 and sex\u2010adjusted incidence from 2011 to 2013 was 8.57 per million per year, and the average age\u2010 and sex\u2010adjusted prevalence from 2009 to 2013 was 47.50 per million population. About 10% of patients presented with complications such as ascites (10.3%), variceal bleeding (5.8%) and\/or hepatocellular carcinoma (\n HCC<\/jats:styled-content>\n ) (1.3%). Liver transplantation was undertaken in 71 patients (2.5%) for 5 years. Case fatality was 2.2% and the transplantation\u2010free survival was 95.4% for 5 years.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This is the first report on the nationwide epidemiology of primary biliary cirrhosis in South Korea, demonstrating lower incidence and prevalence rates than those of Western countries, but a considerable disease burden, representing at least 10% were complicated with decompensated cirrhosis or hepatocellular carcinoma requiring liver transplantation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.13448","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T20:39:09Z","timestamp":1446496749000},"page":"154-162","source":"Crossref","is-referenced-by-count":68,"title":["Population\u2010based epidemiology of primary biliary cirrhosis in South Korea"],"prefix":"10.1111","volume":"43","author":[{"given":"K.\u2010A.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Inje University Ilsan Paik Hospital Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ki","sequence":"additional","affiliation":[{"name":"Department of Cancer Control and Policy Graduate School of Cancer Science and Policy National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Cancer Control and Policy Graduate School of Cancer Science and Policy National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Liver Cancer National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Jang","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010H.","family":"Jeong","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383726"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383725"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383730"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.10.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1995.tb00110.x"},{"key":"e_1_2_7_8_1","volume-title":"Nationwide Survey of Intractable Hepatic Disorders in Japan","author":"Mori MT","year":"1997"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007179"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23210"},{"key":"e_1_2_7_11_1","unstructured":"Korea National Institue of Health.Information for rare intractable diseases. Available at:http:\/\/helpline.nih.go.kr\/cdchelp\/disease.gst?method=detailView%26NO_DISEASE_CODE_SEQ=547%26cateCode=11OMIM_ID=%26searchKind=%26Kof=%26Enf=%26searchWord=%26mediExpenses=%26dic_use=Y%26potalDis=Y%26frm=(accessed June 29 2015)."},{"key":"e_1_2_7_12_1","unstructured":"Korean Statistical Information Service.2010 Population Census. Available at:http:\/\/kosis.kr\/eng\/statisticsList\/statisticsList_01List.jsp?vwcd=MT_ETITLE&parentId=A#SubCont(accessed July 6 2015)."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120116"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-100"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(03)00167-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.12.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.15.24"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20197"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613058"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.029"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328353753d"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36027"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26176"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102014\u2010308351"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.11.035"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00144-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00078-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05223.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.02.019"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8427-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i31.5131"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000313"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13448","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T05:07:03Z","timestamp":1695532023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/apt.13448"],"URL":"https:\/\/doi.org\/10.1111\/apt.13448","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725906657.793511197","asserted-by":"object"}]},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,2]]}}}