{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:42:02Z","timestamp":1790815322047,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001254","name":"Ipsen Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Alterations in serotonin (5\u2010HT<\/jats:styled-content>) metabolism have been postulated to play a role in the pathogenesis of irritable bowel syndrome (IBS<\/jats:styled-content>). However, previous reports regarding 5\u2010HT<\/jats:styled-content> metabolism in IBS<\/jats:styled-content> are contradicting.<\/jats:p><\/jats:sec>Aim<\/jats:title>To compare platelet poor plasma (PPP<\/jats:styled-content>) 5\u2010HT<\/jats:styled-content> and 5\u2010hydroxyindole acetic acid (5\u2010HIAA<\/jats:styled-content>) levels and their ratio in a large cohort of IBS<\/jats:styled-content> patients and healthy controls (HC<\/jats:styled-content>), including IBS<\/jats:styled-content>\u2010subgroup analysis.<\/jats:p><\/jats:sec>Methods<\/jats:title>Irritable bowel syndrome patients and HC<\/jats:styled-content> were evaluated for fasting PPP<\/jats:styled-content> 5\u2010HT<\/jats:styled-content> and 5\u2010HIAA<\/jats:styled-content> levels. Furthermore, GI<\/jats:styled-content>\u2010symptom diary, GSRS<\/jats:styled-content>, quality of life, anxiety and depression scores were assessed in the 2 weeks before blood sampling.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred and fifty four IBS<\/jats:styled-content> patients and 137 HC<\/jats:styled-content> were included. No differences were detected in plasma 5\u2010HT<\/jats:styled-content> between groups. The 5\u2010HIAA<\/jats:styled-content> concentrations and 5\u2010HIAA<\/jats:styled-content>\/5\u2010HT<\/jats:styled-content> ratio were significantly lower in IBS<\/jats:styled-content> compared to HC<\/jats:styled-content>: 24.6 \u00b1 21.9 vs. 39.0 \u00b1 29.5 \u03bcg\/L (P<\/jats:italic> < 0.001) and 8.4 \u00b1 12.2 vs. 13.5 \u00b1 16.6 (P<\/jats:italic> < 0.01), respectively. Subtype analysis for 5\u2010HIAA<\/jats:styled-content> showed all IBS subtypes to be significantly different from HC<\/jats:styled-content>. The 5\u2010HIAA<\/jats:styled-content>\/5\u2010HT<\/jats:styled-content> ratio was significantly lower in the IBS<\/jats:styled-content>\u2010M subtype vs. HC<\/jats:styled-content>. Linear regression analysis points to an influence of gender but not of GI<\/jats:styled-content>\u2010symptoms, psychological scores or medication use.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We demonstrated that fasting 5\u2010HT<\/jats:styled-content> plasma levels are not significantly different in IBS<\/jats:styled-content> patients compared to controls. However, decreased 5\u2010HIAA<\/jats:styled-content> levels and 5\u2010HIAA<\/jats:styled-content>\/5\u2010HT<\/jats:styled-content> ratio in IBS<\/jats:styled-content> patients may reflect altered serotonin metabolism in IBS<\/jats:styled-content>. Gender affects 5\u2010HIAA<\/jats:styled-content> levels in IBS<\/jats:styled-content> patients, but no effects of drugs, such as SSRI<\/jats:styled-content>s, or higher GI<\/jats:styled-content>\u2010symptom or psychological scores were found.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13459","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T07:32:09Z","timestamp":1446708729000},"page":"272-282","source":"Crossref","is-referenced-by-count":77,"title":["Alterations in serotonin metabolism in the irritable bowel syndrome"],"prefix":"10.1111","volume":"43","author":[{"given":"A. Y.","family":"Thijssen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology Department of Internal Medicine Maastricht University Medical Center+ Maastricht The Netherlands"},{"name":"NUTRIM School for Nutrition, and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Mujagic","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology Department of Internal Medicine Maastricht University Medical Center+ Maastricht The Netherlands"},{"name":"NUTRIM School for Nutrition, and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M. A. E.","family":"Jonkers","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology Department of Internal Medicine Maastricht University Medical Center+ Maastricht The Netherlands"},{"name":"NUTRIM School for Nutrition, and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ludidi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology Department of Internal Medicine Maastricht University Medical Center+ Maastricht The Netherlands"},{"name":"NUTRIM School for Nutrition, and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology Department of Internal Medicine Maastricht University Medical Center+ Maastricht The Netherlands"},{"name":"NUTRIM School for Nutrition, and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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