{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:31:48Z","timestamp":1790767908005,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Crohn and Colitis Organisation"},{"name":"EPIMAD Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A better knowledge of the natural history of disabling chronic diseases is essential to improve patient management, evaluate the impact of treatment strategies and provide predictors for disabling disease and comprehensive information for patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To summarise our current knowledge issued from population\u2010based studies of the natural history of ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> (source PubMed) and international conference abstracts, and included all population\u2010based studies that evaluated long\u2010term outcome of paediatric\u2010onset (&lt;17\u00a0years at diagnosis) <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 26 population\u2010based studies were considered in this review from the total of 61 articles or abstracts screened. Most patients presented disease extension and about two\u2010thirds of patients had pancolitis at the end of follow\u2010up. One\u2010half of patients experienced extra\u2010intestinal manifestations and primary sclerosing cholangitis was observed in 5\u201310% of patients. Overall, patients did not appear to have any significant growth retardation or delayed puberty. About two\u2010thirds of patients required corticosteroid therapy and up to 25% were steroid dependent. An increased use of thiopurines was observed and the most recent data indicate that up to one\u2010half of patients were exposed to thiopurines and 10\u201330% were exposed to anti\u2010tumour necrosis factor. One\u2010half of patients required hospitalisations and 20% of patients required colectomy after a follow\u2010up of 10\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Paediatric\u2010onset <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> is characterised by a high rate of disease extension. About 20% of patients had been operated at 10\u2010year follow\u2010up. New population\u2010based studies are needed to evaluate the impact of new treatment strategies comprising immunosuppressants and biologics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13478","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T01:16:42Z","timestamp":1447895802000},"page":"346-355","source":"Crossref","is-referenced-by-count":61,"title":["Review article: the natural history of paediatric\u2010onset ulcerative colitis in population\u2010based studies"],"prefix":"10.1111","volume":"43","author":[{"given":"M.","family":"Fumery","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Epimad Registry Amiens University Hospital Universit\u00e9 de Picardie Jules Verne Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Duricova","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Univerzity Karlovy Prague Czech Republic"},{"name":"EPICOM European Crohn &amp; Colitis Organization Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gower\u2010Rousseau","sequence":"additional","affiliation":[{"name":"EPICOM European Crohn &amp; Colitis Organization Vienna Austria"},{"name":"Public Health, Epidemiology and Economic Health Epimad Registry Maison R\u00e9gionale de la Recherche Clinique Centre Hospitalier Universitaire R\u00e9gional 59037 Lille Cedex France"},{"name":"Lille Inflammation Research International Center LIRIC \u2013 UMR 995 Inserm\/Universit\u00e9 Lille 2\/CHRU de Lille Equipe IBD and Environmental Factors: Epidemiology and Functional Analyses Lille University Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Annese","sequence":"additional","affiliation":[{"name":"EPICOM European Crohn &amp; Colitis Organization Vienna Austria"},{"name":"Division of Gastroenterology AOU Careggi Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Peyrin\u2010Biroulet","sequence":"additional","affiliation":[{"name":"Gastroenterology Inserm U954 University Hospital of Nancy\u2010Brabois Universit\u00e9 Henri Poincar\u00e9 Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Lakatos","sequence":"additional","affiliation":[{"name":"EPICOM European Crohn &amp; Colitis Organization Vienna Austria"},{"name":"1st Department of Medicine Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21349"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.055"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/269076"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.177"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2013.12.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082893"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S40259"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000207"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04857.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.08.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318280b13e"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20558"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21654"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199402000-00008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20962"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mib.0000235835.32176.85"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21559"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21591"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.039"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.06.023"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182a56148"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709000184"},{"key":"e_1_2_8_25_1","article-title":"Postoperative Complications in Pediatric Inflammatory Bowel Disease: A Population\u2010based Study","author":"Penninck E","year":"2015","journal-title":"Inflamm Bowel Dis."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.242"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.249"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.016"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.09.026"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.029"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.081"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.240"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20560"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12873"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01686.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32832a4ed6"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13478","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:55:44Z","timestamp":1695552944000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,18]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/apt.13478"],"URL":"https:\/\/doi.org\/10.1111\/apt.13478","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,18]]}}}