{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:46:25Z","timestamp":1793310385019,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1111\/apt.13496","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T07:06:57Z","timestamp":1449990417000},"page":"534-540","source":"Crossref","is-referenced-by-count":81,"title":["The efficacy of step-down therapy in adult patients with proton pump inhibitor-responsive oesophageal eosinophilia"],"prefix":"10.1111","volume":"43","author":[{"given":"E.","family":"G\u00f3mez-Torrijos","sequence":"first","affiliation":[{"name":"Department of Allergy Hospital; General Universitario de Ciudad Real; Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Garc\u00eda-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital; General Universitario de Ciudad Real; Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Castro-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital; General Universitario de Ciudad Real; Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rodr\u00edguez-Sanchez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology; Hospital General Universitario de Ciudad Real; Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"M\u00e9ndez D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital; General Universitario de Ciudad Real; Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Molina-Infante","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology; Hospital San Pedro de Alcantara; Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"10.1111\/apt.13496-BIB0001|apt13496-cit-0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2011.02.040","article-title":"Eosinophilic esophagitis: updated consensus recommendations for children and adults","volume":"128","author":"Liacouras","year":"2011","journal-title":"J Allerg Clin Immunol"},{"key":"10.1111\/apt.13496-BIB0002|apt13496-cit-0002","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1111\/j.1572-0241.2006.00562.x","article-title":"Eosinophils in the esophagus: peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophilia","volume":"101","author":"Ngo","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/apt.13496-BIB0003|apt13496-cit-0003","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cgh.2010.09.019","article-title":"Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults","volume":"9","author":"Molina-Infante","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/apt.13496-BIB0004|apt13496-cit-0004","article-title":"Efficacy of proton pump inhibitor drugs for inducing clinical and histological remission in patients with symptomatic esophageal eosinophilia: a systematic review and meta-analysis","author":"Lucendo","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/apt.13496-BIB0005|apt13496-cit-0005","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/apt.12513","article-title":"The outcome of patients with oesophageal eosinophilic infiltration after an eight-week trial of a proton pump inhibitor","volume":"38","author":"Vazquez-Elizondo","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13496-BIB0006|apt13496-cit-0006","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1038\/ajg.2013.363","article-title":"Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study","volume":"108","author":"Dellon","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/apt.13496-BIB0007|apt13496-cit-0007","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/apt.12636","article-title":"Eosinophilic oesophagitis and proton pump inhibitor-responsive oesophageal eosinophilia have similar clinical, endoscopic and histological findings","volume":"39","author":"Moawad","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13496-BIB0008|apt13496-cit-0008","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/apt.12914","article-title":"Remission in proton pump inhibitor-responsive esophageal eosinophilia correlates with downregulation of eotaxin-3 and TH2 cytokines, similarly to eosinophilic esophagitis after steroids","volume":"40","author":"Molina-Infante","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/apt.13496-BIB0009|apt13496-cit-0009","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.cgh.2014.02.037","article-title":"Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis","volume":"12","author":"van Rhijn","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/apt.13496-BIB0010|apt13496-cit-0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jaci.2014.08.043","article-title":"Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation","volume":"135","author":"Wen","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/apt.13496-BIB0011|apt13496-cit-0011","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.cgh.2014.07.035","article-title":"eosinophilic esophagitis and proton pump-responsive esophageal eosinophilia: what is in a name?","volume":"12","author":"Katzka","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/apt.13496-BIB0012|apt13496-cit-0012","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1053\/j.gastro.2014.07.055","article-title":"Advances in clinical management of eosinophilic esophagitis","volume":"147","author":"Dellon","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.13496-BIB0013|apt13496-cit-0013","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cgh.2011.01.017","article-title":"Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis","volume":"9","author":"Straumann","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/apt.13496-BIB0014|apt13496-cit-0014","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1053\/j.gastro.2014.04.019","article-title":"Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis","volume":"147","author":"Butz","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.13496-BIB0015|apt13496-cit-0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/MPG.0b013e3182716b7a","article-title":"Effect of proton pump inhibitor on esophageal eosinophilia","volume":"56","author":"Schroeder","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1111\/apt.13496-BIB0016|apt13496-cit-0016","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s10620-011-1991-5","article-title":"Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis","volume":"57","author":"Dohil","year":"2012","journal-title":"Dig Dis Sci"},{"key":"10.1111\/apt.13496-BIB0017|apt13496-cit-0017","first-page":"98","article-title":"Seguridad de los inhibidores de la bomba de protones (IBP)","volume":"103","author":"de Martin Argila","year":"2011","journal-title":"Rev Esp Enferm Dig (Madrid)"},{"key":"10.1111\/apt.13496-BIB0018|apt13496-cit-0018","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1081-1206(10)62660-9","article-title":"Anaphylaxis to omeprazole","volume":"82","author":"Galindo","year":"1999","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1111\/apt.13496-BIB0019|apt13496-cit-0019","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4321\/S1137-66272013000300020","article-title":"Candida esophagitis in an immunocompetent woman. A case report","volume":"36","author":"Palacios Mart\u00ednez","year":"2013","journal-title":"An Sist Sanit Navar"},{"key":"10.1111\/apt.13496-BIB0020|apt13496-cit-0020","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s100960050437","article-title":"Risk factors for esophageal candidiasis","volume":"19","author":"Chocarro Mart\u00ednez","year":"2000","journal-title":"Eur J Microbiol Infect Dis"},{"key":"10.1111\/apt.13496-BIB0021|apt13496-cit-0021","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1586\/17512433.2013.811206","article-title":"Perils and pitfalls of long-term effects of proton pump inhibitors","volume":"6","author":"Wilhelm","year":"2013","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"5 Suppl. 1","key":"10.1111\/apt.13496-BIB0022|apt13496-cit-0022","doi-asserted-by":"crossref","first-page":"S-492","DOI":"10.1016\/S0016-5085(13)61820-X","article-title":"VAS-EoE score: a new symptoms assessment tool for eosinophilic esophagitis","volume":"144","author":"Rodr\u00edguez S\u00e1nchez","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.13496-BIB0023|apt13496-cit-0023","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/ajg.2015.314","article-title":"Long-term loss of response in proton pump inhibitor-responsive esophageal eosinophilia is uncommon and influenced by CYP2C19 genotype and rhinoconjunctivitis","volume":"110","author":"Molina-Infante","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/apt.13496-BIB0024|apt13496-cit-0024","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1053\/j.gastro.2015.02.002","article-title":"Molecular, genetic, and cellular bases for treating eosinophilic esophagitis","volume":"148","author":"Rothenberg","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.13496-BIB0025|apt13496-cit-0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1398-9995.2009.02142.x","article-title":"Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids","volume":"65","author":"Aceves","year":"2010","journal-title":"Allergy"},{"key":"10.1111\/apt.13496-BIB0026|apt13496-cit-0026","article-title":"Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids","author":"Rajan","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/apt.13496-BIB0027|apt13496-cit-0027","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1398-9995.2012.02881.x","article-title":"Dietary therapy can reverse esophageal subepithelial fibrosis in patients with eosinophilic esophagitis: a historical cohort","volume":"67","author":"Lieberman","year":"2012","journal-title":"Allergy"},{"key":"10.1111\/apt.13496-BIB0028|apt13496-cit-0028","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ajg.2013.71","article-title":"ACG Clinical Guideline: evidence based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis","volume":"108","author":"Dellon","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/apt.13496-BIB0029|apt13496-cit-0029","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0773.2004.pto950102.x","article-title":"CYP2C19 polymorphism and proton pump inhibitors","volume":"95","author":"Klotz","year":"2004","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1111\/apt.13496-BIB0030|apt13496-cit-0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2133\/dmpk.20.153","article-title":"Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies","volume":"20","author":"Furuta","year":"2005","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1111\/apt.13496-BIB0031|apt13496-cit-0031","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.clpt.2005.09.012","article-title":"Acid-suppressive effects of rabeprazole, omeprazole, and lansoprazole at reduced and standard doses: a crossover comparative study in homozygous extensive metabolizers of cytochrome P450 2C19","volume":"79","author":"Shimatani","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"10.1111\/apt.13496-BIB0032|apt13496-cit-0032","doi-asserted-by":"crossref","first-page":"e62162","DOI":"10.1371\/journal.pone.0062162","article-title":"Effects of CYP2C19 loss-of function variants on the eradication of H. pylori infection in patients treated with proton pump inhibitor-based triple therapy regimens: a meta analysis of randomized clinical trials","volume":"2013","author":"Tang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1111\/apt.13496-BIB0033|apt13496-cit-0033","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF03262211","article-title":"Individualized therapy for gastroesophageal reflux disease: potential impact of pharmacogenetic testing based on CYP2C19","volume":"16","author":"Furuta","year":"2012","journal-title":"Mol Diagn Ther"},{"key":"10.1111\/apt.13496-BIB0034|apt13496-cit-0034","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.gtc.2014.02.001","article-title":"Steroid treatment of eosinophilic esophagitis in adults","volume":"43","author":"Alexander","year":"2014","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1111\/apt.13496-BIB0035|apt13496-cit-0035","doi-asserted-by":"crossref","first-page":"e0128346","DOI":"10.1371\/journal.pone.0128346","article-title":"Esophageal microbiome in eosinophilic esophagitis","volume":"10","author":"Harris","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1111\/apt.13496-BIB0036|apt13496-cit-0036","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40168-015-0085-6","article-title":"Inflammation-associated microbiota in pediatric eosinophilic esophagitis","volume":"1","author":"Benitez","year":"2015","journal-title":"Microbiome"},{"key":"10.1111\/apt.13496-BIB0037|apt13496-cit-0037","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ajg.2012.443","article-title":"Randomized controlled trial comparing aerosolized swallowed fluticasone to esomeprazole for esophageal eosinophilia","volume":"108","author":"Moawad","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/apt.13496-BIB0038|apt13496-cit-0038","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jaci.2014.07.023","article-title":"Four-food group elimination diet for adult eosinophilic esophagitis: a prospective multicenter study","volume":"134","author":"Molina-Infante","year":"2014","journal-title":"J Allergy Clin Immunol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/apt.13496\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T17:09:54Z","timestamp":1625418594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,2]]}},"URL":"https:\/\/doi.org\/10.1111\/apt.13496","archive":["Portico"],"relation":{},"ISSN":["0269-2813"],"issn-type":[{"value":"0269-2813","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,10]]}}}