{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:01:12Z","timestamp":1789984872973,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Approximately 20% of primary sclerosing cholangitis (\n PSC<\/jats:styled-content>\n ) patients with concomitant inflammatory bowel disease (\n IBD<\/jats:styled-content>\n ) have Crohn's disease (\n CD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To compare\n PSC<\/jats:styled-content>\n \/\n CD<\/jats:styled-content>\n with other\n PSC<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Retrospective study of 240\n PSC<\/jats:styled-content>\n patients diagnosed between 1975 and 2012 (median follow\u2010up 12 years). Activity of\n PSC<\/jats:styled-content>\n at diagnosis was assessed by liver biopsy, Mayo risk and\n ERC<\/jats:styled-content>\n scores. Survival without liver transplantation, number of transplantations and liver\u2010related death were endpoints.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty\u2010three per cent of patients had\n IBD<\/jats:styled-content>\n : 105\n UC<\/jats:styled-content>\n , 32\n CD<\/jats:styled-content>\n and 14\n IBD<\/jats:styled-content>\n unclassified (\n IBD<\/jats:styled-content>\n u).\n IBD<\/jats:styled-content>\n was diagnosed before\n PSC<\/jats:styled-content>\n in 50%. The yearly development of\n PSC<\/jats:styled-content>\n after diagnosing\n IBD<\/jats:styled-content>\n was similar in\n UC<\/jats:styled-content>\n ,\n CD<\/jats:styled-content>\n or\n IBD<\/jats:styled-content>\n u.\n <\/jats:p>\n \n Small\u2010duct\n PSC<\/jats:styled-content>\n was present in 28% of\n PSC<\/jats:styled-content>\n \/\n CD<\/jats:styled-content>\n compared to 3% of\n PSC<\/jats:styled-content>\n \/\n UC<\/jats:styled-content>\n . Small\u2010duct\n PSC<\/jats:styled-content>\n had a markedly better survival than large\u2010duct\n PSC<\/jats:styled-content>\n : no patient developed cholangiocarcinoma or liver\u2010related death, but colorectal cancer occurred in three patients. In large\u2010duct\n PSC<\/jats:styled-content>\n , a more favourable outcome was evident in patients with\n CD<\/jats:styled-content>\n . The liver disease was less progressive: one patient underwent liver transplantation compared to 28% and liver\u2010related deaths were absent compared to 7% in the other\n PSC<\/jats:styled-content>\n groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The prevalence of\n PSC<\/jats:styled-content>\n with concomitant Crohn's disease is relatively rare, but the outcome is more benign than\n PSC<\/jats:styled-content>\n with\n UC<\/jats:styled-content>\n or without\n IBD<\/jats:styled-content>\n . Approximately one\u2010fourth has small\u2010duct\n PSC<\/jats:styled-content>\n . In large\u2010duct\n PSC<\/jats:styled-content>\n \/\n CD<\/jats:styled-content>\n , liver disease is less aggressive and the outcome is much better. The outcome of\n PSC<\/jats:styled-content>\n patients with\n UC<\/jats:styled-content>\n resembled that of\n PSC<\/jats:styled-content>\n without\n IBD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.13516","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T06:58:05Z","timestamp":1452409085000},"page":"612-620","source":"Crossref","is-referenced-by-count":55,"title":["Patients with large\u2010duct primary sclerosing cholangitis and Crohn's disease have a better outcome than those with ulcerative colitis, or without\n IBD<\/scp>"],"prefix":"10.1111","volume":"43","author":[{"given":"J.","family":"Fevery","sequence":"first","affiliation":[{"name":"Hepatology University Hospital Gasthuisberg KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Van Steenbergen","sequence":"additional","affiliation":[{"name":"Hepatology University Hospital Gasthuisberg KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Van Pelt","sequence":"additional","affiliation":[{"name":"Hepatology University Hospital Gasthuisberg KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Laleman","sequence":"additional","affiliation":[{"name":"Hepatology University Hospital Gasthuisberg KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Department of Clinical and Experimental Medicine University Hospital Gasthuisberg KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Geboes","sequence":"additional","affiliation":[{"name":"Pathology University Hospital Gasthuisberg KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vermeire","sequence":"additional","affiliation":[{"name":"Gastroenterology University Hospital Gasthuisberg KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nevens","sequence":"additional","affiliation":[{"name":"Hepatology University Hospital Gasthuisberg KU Leuven Leuven 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