{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:03:26Z","timestamp":1770512606611,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Controversy surrounds the clinical and histological response to topical steroids in patients with eosinophilic oesophagitis (EoE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To perform a systematic review and network meta\u2010analysis of randomised controlled trials to assess the efficacy of topical steroids compared with placebo or proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s) for the management of eosinophilic oesophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cochrane Central Register of Controlled Trials and <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> from inception to 1 July 2015 was searched. Data were extracted independently by two authors. Methodological quality was assessed using the Cochrane risk of bias tool. A network meta\u2010analysis was performed using the Bayesian methods under random\u2010effects multiple treatment comparisons. Results were summarised as odds ratio along with credibility intervals. We also calculated the ranking probability for each treatment based on surface under the cumulative ranking curve (SUCRA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall methodological quality of included studies was low. <jats:styled-content style=\"fixed-case\">SUCRA<\/jats:styled-content> ranking probability indicated that <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> had the highest probability of being the best treatment for achieving histological remission and mean change in eosinophils (0.81 and 0.85, respectively), followed by budesonide (0.74 and 0.63, respectively) and fluticasone (0.5 and 0.5, respectively). None of the comparisons indicated a statistically signicant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results from network meta\u2010analysis show that there is no statistically significant difference between <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>, budesonide and fluticasone for the treatment of EoE as assessed by the histological and clinical response. The evidence is limited by serious risk of bias and imprecision, which emphasises the urgent need for large <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s with adequate sample size and methodological rigour to provide conclusive evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13537","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T08:40:47Z","timestamp":1454316047000},"page":"663-673","source":"Crossref","is-referenced-by-count":35,"title":["Systematic review with network meta\u2010analysis: comparative effectiveness of topical steroids vs. <scp>PPI<\/scp>s for the treatment of the spectrum of eosinophilic oesophagitis"],"prefix":"10.1111","volume":"43","author":[{"given":"S.","family":"Lipka","sequence":"first","affiliation":[{"name":"Division of Digestive Diseases and Nutrition University of South Florida Morsani College of Medicine Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine and Outcomes Research Department of Medicine University of South Florida Morsani College of Medicine Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Miladinovic","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine and Outcomes Research Department of Medicine University of South Florida Morsani College of Medicine Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Richter","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases and Nutrition Joy McCann Culverhouse Center for Swallowing Disorders University of South Florida Morsani College of Medicine Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2014.02.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.71"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.05.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.08.033"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.048"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.03.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0859-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.443"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-79"},{"key":"e_1_2_7_12_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1875"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys124"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-0930"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.04.019"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102014\u2010308815"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.05.021"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(15)30530-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13147"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01179.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010015\u20108501\u2010z"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050037"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572-0241.2003.04018.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800871"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.049"},{"key":"e_1_2_7_31_1","first-page":"59","article-title":"Therapeutic options for eosinophilic esophagitis","volume":"7","author":"Alexander JA","year":"2011","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12977"},{"key":"e_1_2_7_33_1","first-page":"1255","article-title":"A new objective measurement of esophageal lumen patency","volume":"84","author":"Goldschmid S","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.028"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13537","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:08:34Z","timestamp":1695575314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/apt.13537"],"URL":"https:\/\/doi.org\/10.1111\/apt.13537","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}