{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:38:30Z","timestamp":1781969910379,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eosinophilic oesophagitis (EoE) represents a chronic immune\u2010antigen\u2010mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and <jats:italic>H. pylori<\/jats:italic> may play a protective role in these conditions. Little is known about the relationship between EoE and <jats:italic>H. pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate in a case\u2013control study whether <jats:italic>H. pylori<\/jats:italic> infection is associated with a reduced risk of developing EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic> infection was evaluated by serology in 58 [11(19%) female, 47 (81%) male, median age: 36.5 years, range 20\u201372 years] patients with a clinical and histologically proven diagnosis of EoE and 116 age and sex\u2010matched controls (1 case: 2 controls). Antibodies against <jats:italic>H. pylori<\/jats:italic> were identified by enzyme\u2010linked immunosorbent assay. Patients with <jats:italic>H. pylori<\/jats:italic>\u2010specific IgG \u226530 enzyme immunounits were classified as <jats:italic>H. pylori<\/jats:italic>\u2010positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3\/58 (5.2%) patients with EoE had serological evidence of <jats:italic>H. pylori<\/jats:italic> infection (EoE \u2013 <jats:italic>H. pylori<\/jats:italic> current infection) and 5\/58 (8.6%) reported prior eradication therapy for <jats:italic>H. pylori<\/jats:italic> infection (EoE \u2013 <jats:italic>H. pylori<\/jats:italic> former infection). The control group demonstrated significantly higher seroprevalence of <jats:italic>H. pylori<\/jats:italic> (37.9%, <jats:italic>P<\/jats:italic> &lt; 0.0001) when compared to patients with EoE. EoE was inversely associated with <jats:italic>H. pylori<\/jats:italic> infection [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 0.24, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.11\u20130.50].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> infection is inversely associated with EoE. Our results may contribute to further understanding the pathogenesis and evolving aetiology of EoE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13560","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T07:27:02Z","timestamp":1456126022000},"page":"825-830","source":"Crossref","is-referenced-by-count":65,"title":["<i>Helicobacter pylori<\/i> infection is associated with a reduced risk of developing eosinophilic oesophagitis"],"prefix":"10.1111","volume":"43","author":[{"given":"U.","family":"von Arnim","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious diseases Otto\u2010von\u2010Guericke University of Magdeburg Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Wex","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious diseases Otto\u2010von\u2010Guericke University of Magdeburg Magdeburg 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