{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:37:41Z","timestamp":1791607061318,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Reckitt Benckiser"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Many reflux patients remain symptomatic on a standard dose of proton pump inhibitor (\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      ). Alginates decrease the number of reflux events by forming a raft on top of the stomach content and thus offer a supplemental mechanism of action to acid suppression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To assess the efficacy of an alginate (Gaviscon Advance, Reckitt Benckiser, Slough,\n                      <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                      ) on reflux symptoms in patients with persistent symptoms despite once daily\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a multicentre, randomised, placebo\u2010controlled, 7\u2010day double\u2010blind trial preceded by a 7\u2010day run\u2010in period. Reflux symptoms were assessed using the Heartburn Reflux Dyspepsia Questionnaire (HRDQ). Based on symptom score during run\u2010in, eligible patients were randomised to Gaviscon Advance 10\u00a0mL four times a day or placebo in addition to a once daily\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      . The primary endpoint was change in\n                      <jats:styled-content style=\"fixed-case\">HRDQ<\/jats:styled-content>\n                      score post\u2010treatment compared to baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and thirty\u2010six patients were randomised. Change in\n                      <jats:styled-content style=\"fixed-case\">HRDQ<\/jats:styled-content>\n                      reflux score was significantly greater for Gaviscon Advance (mean: \u22125.0, s.d.: 4.7) than for placebo (mean: \u22123.5, s.d.: 5.5) with an\n                      <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n                      mean difference of 1.6 [95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22123.1 to \u22120.1],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.03. A decrease in the mean (s.d.) number of nights with symptoms was observed from 3.6 (2.8) to 3.0 (3.0) in the placebo group and from 3.9 (2.8) to 2.2 (2.7) for the Gaviscon Advance group. This reduction was significantly greater in the Gaviscon Advance group than in the placebo group [\n                      <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n                      mean difference\u00a0=\u00a0\u22120.9, 95% CI (\u22121.6 to \u22120.2),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In patients with residual reflux symptoms despite\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      treatment, adding an alginate offers additional decrease in the burden of reflux symptoms (Eudra\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">IND<\/jats:styled-content>\n                      Number: 2011\u2010005486\u201021).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.13567","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T23:16:23Z","timestamp":1456355783000},"page":"899-909","source":"Crossref","is-referenced-by-count":96,"title":["Randomised clinical trial: alginate (Gaviscon Advance) vs. placebo as add\u2010on therapy in reflux patients with inadequate response to a once daily proton pump inhibitor"],"prefix":"10.1111","volume":"43","author":[{"given":"C.","family":"Reimer","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hvidovre Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"L\u00f8drup","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology K\u00f8ge Hospital K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Smith","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser Brands Slough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser Brands Slough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bytzer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology K\u00f8ge Hospital K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.03.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145581"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32833ae2be"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.10.026"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04358.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.06.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.178061"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27997"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01524.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.046"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12318"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04678.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.01.036"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03451.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03641.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.06.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301897"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04406.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903035745"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.07.008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.087668"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24840"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02489.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.003"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00759.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00424.2014"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13334"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12640"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12482"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2011.01276.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080308"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03189.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.08.045"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13567","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:04:58Z","timestamp":1695546298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,22]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/apt.13567"],"URL":"https:\/\/doi.org\/10.1111\/apt.13567","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726172143.793515677","asserted-by":"object"}]},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,22]]}}}