{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:40Z","timestamp":1787013880857,"version":"build-2736575974"},"reference-count":77,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Microscopic colitis shares certain common clinical manifestations with functional bowel disorders, especially diarrhoea\u2010dominant irritable bowel syndrome (\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      ) and functional diarrhoea. However, the exact relationship between microscopic colitis and functional bowel disorders has not been systematically assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To conduct a systematic review and meta\u2010analysis on the diagnostic overlap between functional bowel disorders and microscopic colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">SCOPUS<\/jats:styled-content>\n                      databases, as well as the abstract books of the major gastroenterology meetings, to investigate the prevalence of microscopic colitis among patients with functional bowel disorders (considering all subtypes of both disorders) and vice versa. Data were pooled with a random\u2010effects model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 227 references identified, data were collected from 26 studies and a total of 5,099 adult patients. The pooled prevalence any type of functional bowel disorders in patients who present diagnostic criteria of microscopic colitis was 39.1% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 22.8\u201356.6%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      : 97%) and was higher for lymphocytic colitis than for collagenous colitis (40.7% vs. 28.4%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.58). The prevalence of microscopic colitis in functional bowel disorders patients was 7% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 3.6\u201311.4%), reaching 9.8% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 4.4\u201317.1%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      : 95%) in patients exhibiting diarrhoea\u2010dominant\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      , nonsignificantly higher than microscopic colitis rates among patients with constipation\u2010dominant\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      (1.3%) or mixed\u2010dominant\n                      <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\n                      (1.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a significant overlap of symptoms between microscopic colitis and functional bowel disorders, especially in diarrhoeal subtypes. The high proportion of microscopic colitis among diarrhoea\u2010dominant functional syndromes should serve as a call for more active diagnosis in selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.13573","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:36:59Z","timestamp":1456439819000},"page":"851-862","source":"Crossref","is-referenced-by-count":62,"title":["Systematic review with meta\u2010analysis: diagnostic overlap of microscopic colitis and functional bowel disorders"],"prefix":"10.1111","volume":"43","author":[{"given":"D.","family":"Guagnozzi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital General Universitario Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Arias","sequence":"additional","affiliation":[{"name":"Research Support Unit Hospital General La Mancha Centro Alc\u00e1zar de San Juan Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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