{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:43:54Z","timestamp":1790808234216,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elimination diets and high\u2010dose proton pump inhibitors (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) are advocated as first\u2010line treatments in patients with eosinophilic oesophagitis (EoE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To record the treatment outcome for patients with EoE prospectively managed according to a clinical algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with oesophageal eosinophilia commenced esomeprazole 40 mg twice daily for 8 weeks. Those in histological remission were re\u2010classified as <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010responsive oesophageal eosinophilia. Nonresponders were offered the 6\u2010food elimination diet with a <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>, or topical budesonide monotherapy (1 mg orally twice daily as an aqueous gel). Once disease control was achieved remission was reassessed at 3 months (all modalities) and an additional 6 months (diet group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 107 patients who completed 8 weeks of <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>, 25 (23%) were <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010responsive. 56 of 81 (69%) of patients with EoE chose the elimination diet with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>. 29 (52%) had complete remission, 23 completed dietary reintroduction and food triggers were identified in 20 (36%). 25 chose budesonide with 23\/25 (92%) responding. Remission was sustained in &gt;85% of patients at 3 months with all treatment modalities. At 9 months, only 10\/18 (55%) of patients who responded to the elimination diet with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> remained complaint and sustained remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many patients previously diagnosed with EoE will respond to <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>. Initial response &gt;50% is possible with the elimination diet plus <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>, but many will fail to undergo food reintroduction, or will cease the diet and relapse, resulting in only one in four patient sustaining remission at 9 months. Budesonide is very effective short term, but longer term study is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13576","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T16:58:03Z","timestamp":1457197083000},"page":"985-993","source":"Crossref","is-referenced-by-count":71,"title":["A prospective open clinical trial of a proton pump inhibitor, elimination diet and\/or budesonide for eosinophilic oesophagitis"],"prefix":"10.1111","volume":"43","author":[{"given":"H.","family":"Philpott","sequence":"first","affiliation":[{"name":"Monash University Melbourne Vic. Australia"},{"name":"Eastern Health Melbourne Vic. Australia"},{"name":"The Alfred Hospital Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nandurkar","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Vic. Australia"},{"name":"Eastern Health Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Royce","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Thien","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Vic. Australia"},{"name":"Eastern Health Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Vic. Australia"},{"name":"The Alfred Hospital Melbourne Vic. 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