{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:53Z","timestamp":1772159993168,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mayo Clinic Gastroenterology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n To date there have been no clear features that aid in differentiating patients with eosinophilic oesophagitis (EoE) from\n PPI<\/jats:styled-content>\n \u2010responsive oesophageal eosinophilia (\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n ). However, barium swallow roentgenography is a more sensitive and specific measure to detect subtle fibrostenotic remodeling changes present in EoE. We aim to characterise any clinical, endoscopic, histiological or barium roentgenographic differences between EoE and\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To characterise any clinical, endoscopic, histiological or barium roentgenographic differences between EoE and\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed a retrospective cohort analysis on data collected from a tertiary referral centre population from 2010 to 2015. Data from 66 patients with EoE and 28 patients with\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n were analysed. Cases were adults who met consensus guidelines for\n EOE<\/jats:styled-content>\n , and had a barium swallow study within 6 months of the index endoscopy. Clinical, endoscopic, histiological and barium swallow findings were collected.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with EoE reported similar characteristics as\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n patients, except EoE patients were younger (35.6 vs. 46.6 years;\n P<\/jats:italic>\n = 0.011), had earlier symptom onset (29.0 vs. 38.0 years;\n P<\/jats:italic>\n = 0.026), and smaller oesophageal diameters on barium swallow (19.5 mm vs. 20;\n P<\/jats:italic>\n = 0.042). Patients with EoE were more likely to have distal strictures (EoE 77% vs. 25%;\n P<\/jats:italic>\n = 0.02) and, importantly, a greater likelihood of small calibre oesophagus (51.5% vs. 17.9%;\n P<\/jats:italic>\n = 0.002). Moreover, EoE patients had a higher probability of developing small calibre oesophagus after 20 years of symptoms (72.3% vs. 30.2%;\n P<\/jats:italic>\n = 0.074) compared to\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n When compared with eosinophilic oesophagitis,\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n patients demonstrate findings that suggest PPI\u2010responsive oesophageal eosinophilia to be a later onset, less aggressive form of oesophageal stricturing disease than eosinophilic oesophagitis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.13601","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T20:13:41Z","timestamp":1459368821000},"page":"1168-1177","source":"Crossref","is-referenced-by-count":25,"title":["Oesophageal narrowing on barium oesophagram is more common in adult patients with eosinophilic oesophagitis than\n PPI<\/scp>\n \u2010responsive oesophageal eosinophilia"],"prefix":"10.1111","volume":"43","author":[{"given":"A.","family":"Podboy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Katzka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Enders","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Geno","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kryzer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.71"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050037"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302250"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12914"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000297"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.07.035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000080"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12636"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.363"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12977"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.12.042"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.10.027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.043"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13141"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04922.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.055"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13601","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:24:33Z","timestamp":1695554673000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,30]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/apt.13601"],"URL":"https:\/\/doi.org\/10.1111\/apt.13601","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726253986.793517767","asserted-by":"object"}]},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,30]]}}}