{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:55:42Z","timestamp":1790740542501,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Results of endovascular interventions in hepatic venous outflow tract obstruction (<jats:styled-content style=\"fixed-case\">HVOTO<\/jats:styled-content>) have been reported from limited studies. Treatment outcomes and prognostic scores need further validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate treatment outcomes and prognostic scores for hepatic venous outflow tract obstruction in an Indian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with hepatic venous outflow tract obstruction diagnosed at a tertiary centre were included. Technical success and clinical response after endovascular interventional therapy were documented. Predictors of survival were assessed with Cox\u2010proportional model. A new score was derived from the factors significant on multivariate analysis and compared with Child\u2013Turcotte\u2013Pugh, model for end\u2010stage liver disease (<jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>), Rotterdam prognostic index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>) and Budd\u2010Chiari syndrome\u2010transjugular intrahepatic portosystemic shunt ( BCS\u2010TIPSS) <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and thirty\u2010four patients (56.6% males), median age 24 (3\u201362) years were included. Hepatic vein was the commonest site of block\u2010isolated hepatic vonous block in 48%, combined hepatic venous\u2010inferior vena cava block in 46%. Endovascular interventional therapy was performed in 233\/334 (70%) with 90% technical success. Clinical response was complete in 166 (71.2%), partial in 58 (24.9%) and no response in nine (3.9%). Majority of cases with <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content> block did not require <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> and could be treated with angioplasty (with\/without stenting). On Cox\u2010proportional multivariate analysis, Child class C and response to intervention were independent predictors of outcome and used to derive the All India Institute of Medical Sciences (AIIMS) hepatic venous outflow tract obstruction score. The 5\u2010year survival was 92% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 81\u201397%) for score \u22643, 79% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 63\u201388%) for score &gt;3 and \u22644, and 39% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 21\u201357%) for score &gt;4. The performance of <jats:styled-content style=\"fixed-case\">AIIMS<\/jats:styled-content> hepatic venous outflow obstruction score was superior to other prognostic indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Advanced Child class and no response to intervention are associated with poor outcomes. The All India Institute of Medical Sciences hepatic venous outflow tract obstruction score predicts survival better than other prognostic scores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13604","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:36:27Z","timestamp":1460309787000},"page":"1154-1167","source":"Crossref","is-referenced-by-count":47,"title":["Hepatic venous outflow tract obstruction: treatment outcomes and development of a new prognostic score"],"prefix":"10.1111","volume":"43","author":[{"family":"Shalimar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kedia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Gamanagatti","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Interventional Radiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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