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To test the predictive accuracy we developed a <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163\u2010fibrosis portal hypertension score in an estimation cohort (<jats:italic>n<\/jats:italic> = 80) and validated the score in an independent cohort (<jats:italic>n<\/jats:italic> = 80). A <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> \u226510 mmHg was considered clinically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>163 and the <jats:styled-content style=\"fixed-case\">ELF<\/jats:styled-content> components increased in a stepwise manner with the patients' Child\u2013Pugh score (<jats:italic>P<\/jats:italic> &lt; 0.001, all), and also with increasing <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001). receiver operator characteristics (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) analyses showed that each one of the individual components predicted a <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> &gt;10 mmHg with <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>\u2032s of approximately 0.80. The combined score optimised by logistic regression analyses improved the <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content> to 0.91 in the estimation cohort and 0.90 in the validation cohort. Furthermore, a high value of the combined score was associated with a high short\u2010term mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of the macrophage activation marker <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>163 and the fibrosis markers predicted significant portal hypertension in patients with cirrhosis. This score may prove useful for screening purposes and highlights the importance of both the inflammatory and the fibrotic components of cirrhotic portal hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13618","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:38:45Z","timestamp":1460309925000},"page":"1222-1231","source":"Crossref","is-referenced-by-count":47,"title":["The macrophage activation marker <scp>sCD<\/scp>163 combined with markers of the Enhanced Liver Fibrosis (<scp>ELF<\/scp>) score predicts clinically significant portal hypertension in patients with cirrhosis"],"prefix":"10.1111","volume":"43","author":[{"given":"T. D.","family":"Sandahl","sequence":"first","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"McGrail","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Reverter","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory Liver Unit Hospital Clinic Institut de Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine 239 Center for Functional and Diagnostic Imaging and Research Faculty of Health Sciences Hvidovre Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Turon","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory Liver Unit Hospital Clinic Institut de Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Hern\u00e1ndez\u2010Gea","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory Liver Unit Hospital Clinic Institut de Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Medical Section Hvidovre Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Vilstrup","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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