{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T22:36:57Z","timestamp":1784587017790,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006209","name":"Radboud Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VICI 016.130.668"],"award-info":[{"award-number":["VICI 016.130.668"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007\u20132013"],"award-info":[{"award-number":["FP7\/2007\u20132013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["305608"],"award-info":[{"award-number":["305608"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proton pump inhibitors (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) are among the most widely prescribed drugs to treat gastric acid\u2010related disorders. PPI\u2010induced hypomagnesaemia, a defect in intestinal absorption of Mg<jats:sup>2+<\/jats:sup>, can be a severe side effect of chronic <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To restore serum Mg<jats:sup>2+<\/jats:sup> concentrations in <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010induced hypomagnesaemia patients by dietary supplementation with inulin fibres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010induced hypomagnesaemia and 10 controls were treated with inulin (20 g\/day). Each trial consisted of two cycles of 14\u2010day inulin treatment followed by a washout period of 14 days. Patients continued to use their <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>. Serum Mg<jats:sup>2+<\/jats:sup> levels served as the primary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inulin significantly enhanced serum Mg<jats:sup>2+<\/jats:sup> levels from 0.60 to 0.68 mmol\/L in <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010induced hypomagnesaemia patients, and from 0.84 to 0.93 mmol\/L in controls. As a consequence 24 h urinary Mg<jats:sup>2+<\/jats:sup> excretion was significantly increased in patients with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010induced hypomagnesaemia (0.3\u20132.2 mmol\/day). Symptoms related to hypomagnesaemia, including muscle cramps and paraesthesia, were reduced during intervention with inulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inulin increases serum Mg<jats:sup>2+<\/jats:sup> concentrations under <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> maintenance in patients with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010induced hypomagnesaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13619","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T10:44:18Z","timestamp":1460976258000},"page":"1178-1185","source":"Crossref","is-referenced-by-count":20,"title":["Inulin significantly improves serum magnesium levels in proton pump inhibitor\u2010induced hypomagnesaemia"],"prefix":"10.1111","volume":"43","author":[{"given":"M. W.","family":"Hess","sequence":"first","affiliation":[{"name":"Department of Physiology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H. F.","family":"de Baaij","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Broekman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. M.","family":"Bisseling","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Haarhuis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Bernhoven Hospital Uden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Canisius\u2010Wilhelmina\u2010Hospital Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"te Morsche","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G. J.","family":"Hoenderop","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J. M.","family":"Bindels","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P. H.","family":"Drenth","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.64"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3104-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.452"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.316"},{"key":"e_1_2_7_6_1","unstructured":"FDA.Low magnesium levels can be associated with long\u2010term use of proton pump inhibitor drugs (PPIs). 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