{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:36:39Z","timestamp":1784115399006,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:00:00Z","timestamp":1460419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3A0221"],"award-info":[{"award-number":["CMRPG3A0221"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3A0222"],"award-info":[{"award-number":["CMRPG3A0222"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3A0223"],"award-info":[{"award-number":["CMRPG3A0223"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NMRPG104\u20102314\u2010B\u2010182A\u2010028\u2010MY2"],"award-info":[{"award-number":["NMRPG104\u20102314\u2010B\u2010182A\u2010028\u2010MY2"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Both spontaneous and nucleos(t)ide analogue (Nuc)\u2010treated hepatitis B surface antigen (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg) seroclearance are associated with excellent clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To conduct a case\u2013control study to explore whether there is difference of clinical outcomes between these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 312 chronic hepatitis B patients with spontaneous <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance and 110 patients with Nuc\u2010treated <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance were recruited retrospectively. Propensity score (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) matching method produced 98 patients in each group for comparison. The development of hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>), hepatic complications and cumulative incidence of antibody to <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg (anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s) was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean follow\u2010up period of 107 months after <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance, five patients developed <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> after a mean period of 75.3 months (four and one patients with spontaneous and Nuc\u2010treated <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance, respectively) in overall population. One died of pneumonia with sepsis and one experienced variceal bleeding in Nuc\u2010treated patients but none in spontaneous group. The incidence of anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s seroconversion was comparable between spontaneous and Nuc\u2010treated <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance (69.6% vs. 66.4%, respectively, <jats:italic>P<\/jats:italic> = 0.617). There were no significant differences in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> development (2% vs. 1.1%), overall mortality (0% vs. 1%), variceal bleeding (0% vs. 4.2%) and 6\u2010year cumulative incidence of anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s seroconversion (62.3% vs. 61.5%) among <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>\u2010matched patients with spontaneous and Nuc\u2010treated <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical outcomes between patients with spontaneous and Nuc\u2010treated <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance are comparable. <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> can develop at a low rate during long\u2010term follow\u2010up and periodic surveillance after <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance is still mandatory.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13630","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T05:26:12Z","timestamp":1460525172000},"page":"1311-1318","source":"Crossref","is-referenced-by-count":39,"title":["Clinical outcomes after spontaneous and nucleos(t)ide analogue\u2010treated <scp>HB<\/scp>sAg seroclearance in chronic <scp>HBV<\/scp> infection"],"prefix":"10.1111","volume":"43","author":[{"given":"Y. C.","family":"Chen","sequence":"first","affiliation":[{"name":"Liver Research Unit Chang Gung Memorial Hospital Chang Gung University College of Medicine Taipei Taiwan"},{"name":"Division of Hepatology Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Jeng","sequence":"additional","affiliation":[{"name":"Liver Research Unit Chang Gung Memorial Hospital Chang Gung University College of Medicine Taipei Taiwan"},{"name":"Division of Hepatology Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. N.","family":"Chien","sequence":"additional","affiliation":[{"name":"Liver Research Unit Chang Gung Memorial Hospital Chang Gung University College of Medicine Keelung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Chu","sequence":"additional","affiliation":[{"name":"Liver Research Unit Chang Gung Memorial Hospital Chang Gung University College of Medicine Taipei Taiwan"},{"name":"Division of Hepatology Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. F.","family":"Liaw","sequence":"additional","affiliation":[{"name":"Liver Research Unit Chang Gung Memorial Hospital Chang Gung University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60207-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1497"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36026"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20240"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.10.026"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.02.033"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.031"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23464"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3486-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01542.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26376"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0688-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305517"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0821-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010015\u20101128\u20102"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33638"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3194-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.059"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3775-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21612"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870210502"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13409"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90919-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20933"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2343-9"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9365-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22962"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074999"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13630","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.13630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:31:56Z","timestamp":1695537116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/apt.13630"],"URL":"https:\/\/doi.org\/10.1111\/apt.13630","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,12]]}}}