{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:28:41Z","timestamp":1785288521482,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Sweden, the most common causes of liver cirrhosis are alcohol overconsumption and hepatitis C. However, recent data on the clinical characteristics of Swedish patients with cirrhosis are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the incidence, clinical presentation, aetiological spectrum and survival rates of liver cirrhosis in Southern Sweden from 2001 to 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used population\u2010based medical registries to conduct a cohort study of all patients with liver cirrhosis in the southernmost region of Sweden with a population of 1.17 million. Medical records and histopathology data were reviewed. Patients were classified according to aetiology, and clinical parameters were registered. Patients were followed until death or December 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1317 patients with cirrhosis were identified. The crude annual incidence of cirrhosis was estimated at 14.1\/100\u00a0000. The most common aetiology was alcohol overconsumption with or without additional causes of cirrhosis (58%) followed by <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> alone (13%) and cryptogenic cirrhosis (12%). At diagnosis, ascites occurred in 43%, variceal bleeding in 6% and overt encephalopathy in 4%. The median follow\u2010up was 4.3\u00a0years. The total 1\u2010, 5\u2010 and 10\u2010year survival rates were 79%, 47% and 27% respectively. Survival rates were better for women than for men. A 10\u2010year cumulative incidence of transplantation was 7.3%. Mortality was worst for alcoholic cirrhosis with concomitant <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> when adjusted for age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sweden continues to have a low incidence of cirrhosis compared with other European countries. Mortality varies with gender, aetiology and severity at diagnosis. Patients with alcoholic cirrhosis with concomitant <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection fare worst.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13635","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T07:54:09Z","timestamp":1461052449000},"page":"1330-1339","source":"Crossref","is-referenced-by-count":50,"title":["Incidence, clinical presentation and mortality of liver cirrhosis in Southern Sweden: a 10\u2010year population\u2010based study"],"prefix":"10.1111","volume":"43","author":[{"given":"E.","family":"Nilsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Gastroenterology Clinic Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cancer Epidemiology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sargenti","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Gastroenterology Clinic Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Gastroenterology Clinic Sk\u00e5ne University Hospital Lund University Lund Sweden"},{"name":"Department of Clinical Sciences Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Prytz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Gastroenterology Clinic Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0145-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.12.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520902912571"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.661759"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000317248"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00531-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_8_11_1","unstructured":"Age\u2010standardised mortality rate calculation template 1976. 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