{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:20:34Z","timestamp":1760955634084,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["ZonMW 120720012"],"award-info":[{"award-number":["ZonMW 120720012"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006020","name":"Center for Translational Molecular Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006020","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Faecal immunochemical testing (<jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content>) for colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) screening has suboptimal sensitivity for detecting advanced neoplasia. To increase its performance, <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content> could be combined with other risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the incremental yield of a screening programme using a positive <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content> or a <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> family history, to offer a diagnostic colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this <jats:italic>post hoc<\/jats:italic> analysis, data were collected in the colonoscopy arm of a colonoscopy or colonography for screening study. In this study, 6600 randomly selected, asymptomatic men and women (50\u201375 years) were invited for screening colonoscopy. 1112 Participants completed a <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content> and a questionnaire prior to colonoscopy. We compared the yield of <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content>\u2010only and <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content> combined with <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> family history, defined as having one or more first\u2010degree relatives with <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a 10 \u03bcg Hb\/g faeces <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content>\u2010positivity threshold the combined strategy would increase the yield from 36 (3.2%; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.4\u20134.5%) to 53 (4.8%; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.7\u20136.2%) cases of advanced neoplasia, at the expense of 148 additional negative colonoscopies. Sensitivity in detecting advanced neoplasia would increase from 36% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 26\u201346%) to 52% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 42\u201363%), whereas specificity would decrease from 93% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 92\u201395%) to 79% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 76\u201381%). The strategy will be preferred if one accepts 8.8 false positives for every additional participant in whom advanced neoplasia can be detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Offering colonoscopy to those with a positive <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> family history increases the yield of a <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content>\u2010based screening programme. Depending on the number of negative colonoscopies one accepts, this combined approach can be considered for improving <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13660","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T06:27:33Z","timestamp":1463034453000},"page":"88-96","source":"Crossref","is-referenced-by-count":7,"title":["Adding family history to faecal immunochemical testing increases the detection of advanced neoplasia in a colorectal cancer screening programme"],"prefix":"10.1111","volume":"44","author":[{"given":"F. G. J.","family":"Kallenberg","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L. 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