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Incident cases of EoE were diagnosed per consensus guidelines. Controls were subjects with either <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> or dysphagia without EoE. EoE patients were treated with swallowed\/topical steroids and had repeat endoscopy\/biopsy. Serum periostin levels for cases and controls were compared at baseline, and pre\/post\u2010treatment levels were compared for cases. Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 and tissue expression of periostin were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 61 incident EoE cases and 87 controls were analysed. Despite a marked increase in tissue periostin expression in cases, the median baseline serum periostin level was only slightly higher in cases than controls (22.1 ng\/mL vs. 20.7; <jats:italic>P<\/jats:italic> = 0.04); there was no change in post\u2010treatment levels. There was also no difference in serum periostin for cases by histologic response or atopic status. There was a strong trend towards higher serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 levels in cases in the highest periostin quartile (57.1 pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> vs. 2.6; <jats:italic>P<\/jats:italic> = 0.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum periostin levels were similar in cases and controls, and there were no changes post\u2010treatment. Given elevated <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 levels in the EoE patients with the highest periostin levels, future studies could explore periostin as a biomarker in EoE, perhaps in the setting of anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13672","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T07:40:45Z","timestamp":1463643645000},"page":"189-197","source":"Crossref","is-referenced-by-count":37,"title":["Prospective assessment of serum periostin as a biomarker for diagnosis and monitoring of eosinophilic oesophagitis"],"prefix":"10.1111","volume":"44","author":[{"given":"E. 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L.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Center for Esophageal Diseases and Swallowing University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Beitia","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Center for Esophageal Diseases and Swallowing University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rusin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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