{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:32:55Z","timestamp":1793723575452,"version":"4.6.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of allergy tests to guide dietary treatment for eosinophilic oesophagitis (EoE) is controversial and data are limited. Aeroallergen sensitisation patterns and food triggers have been defined in Northern Hemisphere cohorts only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine if allergy tests that are routinely available can predict food triggers in adult patients with EoE. To define the food triggers and aeroallergen sensitisation patterns in a novel Southern Hemisphere (Australian) cohort of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with EoE who elected to undergo dietary therapy were prospectively assessed, demographic details and atopic characteristics recorded, and allergy tests, comprising skin\u2010prick and skin\u2010patch tests, serum allergen\u2010specific IgE, basophil activation test and serum food\u2010specific IgG, were performed. Patients underwent a six\u2010food elimination diet with a structured algorithm that included endoscopic and histological examination of the oesophagus a minimum of 2 weeks after each challenge. Response was defined as &lt;15 eosinophils per <jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>. Foods defined as triggers were considered as gold standard and were compared with those identified by allergy testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No allergy test could accurately predict actual food triggers. Concordance among skin\u2010prick and serum allergen\u2010specific IgE was high for aeroallergens only. Among seasonal aeroallergens, rye\u2010grass sensitisation was predominant. Food triggers were commonly wheat, milk and egg, alone or in combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>None of the currently\u2010available allergy tests predicts food triggers for EoE. Exclusion\u2010rechallenge methodology with oesophageal histological assessment remains the only effective investigation. The same food triggers were identified in this southern hemisphere cohort as previously described.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13676","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T08:08:57Z","timestamp":1464768537000},"page":"223-233","source":"Crossref","is-referenced-by-count":111,"title":["Allergy tests do not predict food triggers in adult patients with eosinophilic oesophagitis. A comprehensive prospective study using five modalities"],"prefix":"10.1111","volume":"44","author":[{"given":"H.","family":"Philpott","sequence":"first","affiliation":[{"name":"Monash University Melbourne Vic. Australia"},{"name":"Eastern Health Department of Gastroenterology Eastern Health Clinical School Melbourne Vic. Australia"},{"name":"The Alfred Hospital Melbourne Vic. 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