{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T11:41:25Z","timestamp":1775994085401,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Incidence and complications of peptic ulcer disease (<jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>) have declined, but mortality from peptic ulcer bleeding has remained unchanged. The few recent studies on mortality associated with both uncomplicated and complicated patients with peptic ulcer disease provide contradictory results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate short\u2010 and long\u2010term mortality, and the main causes of death in peptic ulcer disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective epidemiologic cohort study, register data on 8146 adult patients hospitalised with peptic ulcer disease during 2000\u20132008 were collected in the capital region of Finland. All were followed in the National Cause of Death Register until the end of 2009. The data were linked with the nationwide Drug Purchase Register of the Finnish Social Insurance Institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean follow\u2010up time was 4.9 years. Overall mortality was substantially increased, standardised mortality ratio 2.53 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.44\u20132.63); 3.7% died within 30 days, and 11.8% within 1 year. At 6 months, the survival of patients with perforated or bleeding ulcer was lower compared to those with uncomplicated ulcer; hazard ratios were 2.06 (1.68\u20132.04) and 1.32 (1.11\u20131.58), respectively. For perforated duodenal ulcers, both the short\u2010 and long\u2010term survival was significantly impaired in women. The main causes of mortality at 1 year were malignancies and cardiovascular diseases. Previous use of statins was associated with significant reduction in all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One\u2010year mortality in patients hospitalised with peptic ulcer disease remained high with no change. This peptic ulcer disease cohort had a clearly decreased survival rate up to 10 years, especially among women with a perforated duodenal ulcer, most likely explained by poorer survival due to underlying comorbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13682","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T04:12:57Z","timestamp":1464667977000},"page":"234-245","source":"Crossref","is-referenced-by-count":26,"title":["Increased short\u2010 and long\u2010term mortality in 8146 hospitalised peptic ulcer patients"],"prefix":"10.1111","volume":"44","author":[{"given":"H.","family":"Malmi","sequence":"first","affiliation":[{"name":"Gastrointestinal Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kautiainen","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Health Care Helsinki University Hospital University of Helsinki Helsinki Finland"},{"name":"Department of General Practice and Primary Health Care University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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