{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:00:00Z","timestamp":1781571600383,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity and overweight are global health problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the diagnostic accuracy of liver stiffness measurement (<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>) using acoustic radiation force impulse (<jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content>) elastography in overweight and obese patients for staging liver fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010seven patients (mean age: 50 years, 50% male) with body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) \u226525 kg\/m<jats:sup>2<\/jats:sup> (mean <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>: 31 kg\/m<jats:sup>2<\/jats:sup>) were prospectively enrolled. All patients underwent <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> elastography and liver biopsy. In 87\/97 patients, transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>) was performed (M\u2010 and <jats:styled-content style=\"fixed-case\">XL<\/jats:styled-content>\u2010probes). Patients were divided into two groups respectively: overweight: <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &lt;30 kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic> = 61); and obese: <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> \u226530 kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic> = 26).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acoustic radiation force impulse elastography correlated with liver fibrosis in overweight (<jats:italic>r<\/jats:italic> = 0.84, <jats:italic>P<\/jats:italic> &lt; 0.0001) and obese patients (<jats:italic>r<\/jats:italic> = 0.85, <jats:italic>P<\/jats:italic> &lt; 0.0001), while no correlation was observed with steatosis, steatohepatitis and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. Area under the curve detecting liver cirrhosis for <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> were 0.97 in overweight and 0.94 and 0.92 in obese patients. In both groups, the failure rate was lower for <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> of liver segment 8 showed a lower discordance than <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> in both groups (overweight: 3% vs. 12%, <jats:italic>P<\/jats:italic> = 0.002; obese: 8% vs. 27%, <jats:italic>P<\/jats:italic> = 0.034). Steatosis and steatohepatitis were neither predictors of discordance nor of performance in <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> by <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In overweight and obese patients, acoustic radiation force impulse can diagnose liver cirrhosis and significant fibrosis with high diagnostic accuracy. Liver stiffness measurement using the <jats:styled-content style=\"fixed-case\">XL<\/jats:styled-content>\u2010probe reduces the influence of <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, steatosis and steatohepatitis. The failure and discordance rates were lower for acoustic radiation force impulse than transient elastography in both patients groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13710","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T02:29:52Z","timestamp":1467340192000},"page":"366-379","source":"Crossref","is-referenced-by-count":28,"title":["Liver stiffness measurement using acoustic radiation force impulse elastography in overweight and obese patients"],"prefix":"10.1111","volume":"44","author":[{"given":"D.","family":"Attia","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School Hannover Germany"},{"name":"Department of Gastroenterology Hepatology and Endemic Medicine Faculty of Medicine Beni Suef University Beni Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bantel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lenzen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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