{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:27:53Z","timestamp":1790195273653,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Azienda Ospedaliera di Padova"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the relationship between proton pump inhibitor\u2010responsive oesophageal eosinophilia (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>), eosinophilic esophagitis (EoE) and gastro\u2010oesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare high resolution manometry features and symptom profiles of patients with EoE, <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients diagnosed with EoE or <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> according to international criteria (presence of at least one typical symptom of oesophageal dysfunction; at least 15 eosinophils per high\u2010power field at mid\/proximal oesophagus, persistence or resolution of eosinophils after an 8\u2010week <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> trial), and a group of patients with proven <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> and oesophageal eosinophilia, prospectively completed the GerdQ questionnaire and underwent high resolution manometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five patients with EoE, 17 with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> and 27 with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> were enrolled. When compared to <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>, both EoE and <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> had higher rates of dysphagia (15% vs. 94% vs. 88%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), patients with EoE reported heartburn and regurgitation less frequently (26% vs. 85%, and 17% vs. 74%, respectively; <jats:italic>P<\/jats:italic> &lt; 0.001 for each and had lower GerdQ score [1 (0\u20136) vs. 8 (6\u201312), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] than <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients. There was no significant difference comparing PPI\u2010REE and GERD patients. Patients with PPI\u2010REE had a higher prevalence of erosive oesophagitis than patients with EoE (35% vs. 9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), which was similar to that of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> (48%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.54). Patients with EoE had a lower frequency of high resolution manometry features associated with GERD than patients with PPI\u2010REE. There was no significant difference between PPI\u2010REE and GERD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GERD, as assessed by GerdQ and high resolution manometry is common in patients with PPI\u2010REE, which may share similar pathogenic mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13718","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T09:03:13Z","timestamp":1467622993000},"page":"522-530","source":"Crossref","is-referenced-by-count":45,"title":["The GerdQ questionnaire and high resolution manometry support the hypothesis that proton pump inhibitor\u2010responsive oesophageal eosinophilia is a <scp>GERD<\/scp>\u2010related phenomenon"],"prefix":"10.1111","volume":"44","author":[{"given":"E. 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