{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:17:04Z","timestamp":1791587824078,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000149","name":"Canadian Association of Gastroenterology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A gluten\u2010free diet is the only recommended treatment for coeliac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the prevalence and characteristics of reactions to gluten among persons with coeliac disease on a gluten\u2010free diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with biopsy proven, newly diagnosed coeliac disease were prospectively enrolled. A survey related to diet adherence and reactions to gluten was completed at study entry and 6 months. The Coeliac Symptom Index, Coeliac Diet Assessment Tool (<jats:styled-content style=\"fixed-case\">CDAT<\/jats:styled-content>) and Gluten\u2010Free Eating Assessment Tool (<jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EAT<\/jats:styled-content>) were used to measure coeliac disease symptoms and gluten\u2010free diet adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 105 participants, 91% reported gluten exposure &lt;1 per month and median <jats:styled-content style=\"fixed-case\">CDAT<\/jats:styled-content> score was 9 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 8\u201311), consistent with adequate adherence. A suspected symptomatic reaction to gluten was reported by 66%. Gluten consumption was unsuspected until a reaction occurred (63%) or resulted from problems ordering in a restaurant (29%). The amount of gluten consumed ranged from cross\u2010contact (30%) to a major ingredient (10%). Median time to symptom onset was 1 h (range 10 min to 48 h), and median symptom duration was 24 h (range 1 h to 8 days). Common symptoms included abdominal pain (80%), diarrhoea (52%), fatigue (33%), headache (30%) and irritability (29%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reactions to suspected gluten exposure are common among patients with coeliac disease on a gluten\u2010free diet. Eating at restaurants and other peoples\u2019 homes remain a risk for unintentional gluten exposure. When following individuals with coeliac disease, clinicians should include questions regarding reactions to gluten as part of their assessment of gluten\u2010free diet adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.13725","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T07:08:46Z","timestamp":1469171326000},"page":"612-619","source":"Crossref","is-referenced-by-count":74,"title":["Symptomatic suspected gluten exposure is common among patients with coeliac disease on a gluten\u2010free diet"],"prefix":"10.1111","volume":"44","author":[{"given":"J. A.","family":"Silvester","sequence":"first","affiliation":[{"name":"College of Medicine University of Manitoba Winnipeg MB Canada"},{"name":"Celiac Research Program Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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